Molecular genetic aspects of the Romano-Ward long QT syndrome

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The Romano-Ward long QT syndrome, an autosomal dominant inherited disorder, is an increasingly recognized cause of sudden cardiac death in children and adults. Sudden death may or may not be preceded by a history of 'seizures' and recurrent syncope, the diagnosis relies on electrocardiographic evidence, including prolongation of the Q1 interval corrected for heart rate, T wave abnormalities, sinus bradycardia, and polymorphous ventricular tachycardia (torsades de pointes). Recently, a gene responsible for causing long QT syndrome was localized (using molecular genetic methods) to the short arm of chromosome 11 (11p15.5) in the region near the Harvey ras-1 locus. The purpose of this report is to describe the current molecular genetic understanding of long QT syndrome, including information regarding gene mapping, genetic heterogeneity, and prenatal or presymptomatic diagnosis.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalTexas Heart Institute Journal
Volume21
Issue number1
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Long QT Syndrome
Molecular Biology
Torsades de Pointes
Chromosomes, Human, Pair 11
Genetic Heterogeneity
Chromosome Mapping
Sudden Cardiac Death
Syncope
Bradycardia
Ventricular Tachycardia
Sudden Death
Seizures
Heart Rate
Genes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Molecular genetic aspects of the Romano-Ward long QT syndrome. / Towbin, Jeffrey.

In: Texas Heart Institute Journal, Vol. 21, No. 1, 01.01.1994, p. 42-47.

Research output: Contribution to journalReview article

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