Molecular genetic influences on normative and problematic alcohol use in a population-based sample of college students

Bradley T. Webb, Alexis C. Edwards, Aaron Wolen, Jessica E. Salvatore, Fazil Aliev, Brien P. Riley, Cuie Sun, Vernell S. Williamson, James N. Kitchens, Kimberly Pedersen, Amy Adkins, Megan E. Cooke, Jeanne E. Savage, Zoe Neale, Seung B. Cho, Danielle M. Dick, Kenneth S. Kendler

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. Examination of the effects of individual variants as well as aggregate genetic variation can clarify mechanisms underlying risk. Methods: We conducted genome-wide association studies (GWAS) in an ethnically diverse sample of college students for three quantitative outcomes including typical monthly alcohol consumption, alcohol problems, and maximum number of drinks in 24 h. Heritability based on common genetic variants (h2SNP) was assessed. We also evaluated whether risk variants in aggregate were associated with alcohol use outcomes in an independent sample of young adults. Results: Two genome-wide significant markers were observed: rs11201929 in GRID1 for maximum drinks in 24 h, with supportive evidence across all ancestry groups; and rs73317305 in SAMD12 (alcohol problems), tested only in the African ancestry group. The h2SNP estimate was 0.19 (SE = 0.11) for consumption, and was non-significant for other outcomes. Genome-wide polygenic scores were significantly associated with alcohol outcomes in an independent sample. Conclusions: These results robustly identify genetic risk for alcohol use outcomes at the variant level and in aggregate. We confirm prior evidence that genetic variation in GRID1 impacts alcohol use, and identify novel loci of interest for multiple alcohol outcomes in emerging adults. These findings indicate that genetic variation influencing normative and problematic alcohol use is, to some extent, convergent across ancestry groups. Studying college populations represents a promising avenue by which to obtain large, diverse samples for gene identification.

Original languageEnglish (US)
Article number30
JournalFrontiers in Genetics
Volume8
Issue numberMAR
DOIs
StatePublished - Mar 15 2017

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Molecular Biology
Alcohols
Students
Population
Genome
Genome-Wide Association Study
Alcohol Drinking
Young Adult
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

Cite this

Molecular genetic influences on normative and problematic alcohol use in a population-based sample of college students. / Webb, Bradley T.; Edwards, Alexis C.; Wolen, Aaron; Salvatore, Jessica E.; Aliev, Fazil; Riley, Brien P.; Sun, Cuie; Williamson, Vernell S.; Kitchens, James N.; Pedersen, Kimberly; Adkins, Amy; Cooke, Megan E.; Savage, Jeanne E.; Neale, Zoe; Cho, Seung B.; Dick, Danielle M.; Kendler, Kenneth S.

In: Frontiers in Genetics, Vol. 8, No. MAR, 30, 15.03.2017.

Research output: Contribution to journalArticle

Webb, BT, Edwards, AC, Wolen, A, Salvatore, JE, Aliev, F, Riley, BP, Sun, C, Williamson, VS, Kitchens, JN, Pedersen, K, Adkins, A, Cooke, ME, Savage, JE, Neale, Z, Cho, SB, Dick, DM & Kendler, KS 2017, 'Molecular genetic influences on normative and problematic alcohol use in a population-based sample of college students', Frontiers in Genetics, vol. 8, no. MAR, 30. https://doi.org/10.3389/fgene.2017.00030
Webb, Bradley T. ; Edwards, Alexis C. ; Wolen, Aaron ; Salvatore, Jessica E. ; Aliev, Fazil ; Riley, Brien P. ; Sun, Cuie ; Williamson, Vernell S. ; Kitchens, James N. ; Pedersen, Kimberly ; Adkins, Amy ; Cooke, Megan E. ; Savage, Jeanne E. ; Neale, Zoe ; Cho, Seung B. ; Dick, Danielle M. ; Kendler, Kenneth S. / Molecular genetic influences on normative and problematic alcohol use in a population-based sample of college students. In: Frontiers in Genetics. 2017 ; Vol. 8, No. MAR.
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AU - Riley, Brien P.

AU - Sun, Cuie

AU - Williamson, Vernell S.

AU - Kitchens, James N.

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AU - Adkins, Amy

AU - Cooke, Megan E.

AU - Savage, Jeanne E.

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AU - Cho, Seung B.

AU - Dick, Danielle M.

AU - Kendler, Kenneth S.

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