Molecular mechanisms of adhesion, colonization, and invasion of group A streptococci

Harry Courtney, David L. Hasty, James Dale

Research output: Contribution to journalReview article

122 Citations (Scopus)

Abstract

The initial step in establishing a bacterial infection is adhesion of the organism to the epithelium of the host. Group A streptococci use multiple adhesins to attach to host cells and the types of adhesins expressed by a particular strain will determine its tissue specificity. Expression of adhesins is regulated in response to changing environmental and growth conditions. Thus, the array of adhesins expressed by a group A streptococcus will depend on the complement of its adhesin genes and on the environment. Expression of some adhesins may trigger internalization of the streptococci by host cells, which may enable the streptococci to evade antibiotics and to facilitate the penetration of deeper tissues. In this review, we present the different molecular mechanisms of adhesion utilized by group A streptococci and how these interactions lead to colonization and invasion.

Original languageEnglish (US)
Pages (from-to)77-87
Number of pages11
JournalAnnals of Medicine
Volume34
Issue number2
DOIs
StatePublished - Jun 17 2002

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Streptococcus
Organ Specificity
Bacterial Infections
Epithelium
Anti-Bacterial Agents
Growth
Genes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Molecular mechanisms of adhesion, colonization, and invasion of group A streptococci. / Courtney, Harry; Hasty, David L.; Dale, James.

In: Annals of Medicine, Vol. 34, No. 2, 17.06.2002, p. 77-87.

Research output: Contribution to journalReview article

Courtney, Harry ; Hasty, David L. ; Dale, James. / Molecular mechanisms of adhesion, colonization, and invasion of group A streptococci. In: Annals of Medicine. 2002 ; Vol. 34, No. 2. pp. 77-87.
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