Molecular organization of the gene encoding murine transforming growth factor β1

Charanjeet Guron, Chitra Sudarshan, Rajendra Raghow

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A detailed restriction map of the murine TGF-β1 locus (encoding transforming growth factor β1) was established and the precise junctional sequences of its seven exons and corresponding introns were elucidated. While the exons ranged in size from 78 to 357 bp, the introns ranged from about 1 to 6.5 kb. The promoter-proximal segment contains many putative regulatory motifs which may dictate TGF-βl gene transcription in response to varied pathophysiological stimuli.

Original languageEnglish (US)
Pages (from-to)325-326
Number of pages2
JournalGene
Volume165
Issue number2
DOIs
StatePublished - Jan 1 1995

Fingerprint

Transforming Growth Factors
Introns
Exons
Genes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Molecular organization of the gene encoding murine transforming growth factor β1. / Guron, Charanjeet; Sudarshan, Chitra; Raghow, Rajendra.

In: Gene, Vol. 165, No. 2, 01.01.1995, p. 325-326.

Research output: Contribution to journalArticle

Guron, Charanjeet ; Sudarshan, Chitra ; Raghow, Rajendra. / Molecular organization of the gene encoding murine transforming growth factor β1. In: Gene. 1995 ; Vol. 165, No. 2. pp. 325-326.
@article{118c80e4793e4aafb20bcad66fc946eb,
title = "Molecular organization of the gene encoding murine transforming growth factor β1",
abstract = "A detailed restriction map of the murine TGF-β1 locus (encoding transforming growth factor β1) was established and the precise junctional sequences of its seven exons and corresponding introns were elucidated. While the exons ranged in size from 78 to 357 bp, the introns ranged from about 1 to 6.5 kb. The promoter-proximal segment contains many putative regulatory motifs which may dictate TGF-βl gene transcription in response to varied pathophysiological stimuli.",
author = "Charanjeet Guron and Chitra Sudarshan and Rajendra Raghow",
year = "1995",
month = "1",
day = "1",
doi = "10.1016/0378-1119(95)00460-N",
language = "English (US)",
volume = "165",
pages = "325--326",
journal = "Gene",
issn = "0378-1119",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Molecular organization of the gene encoding murine transforming growth factor β1

AU - Guron, Charanjeet

AU - Sudarshan, Chitra

AU - Raghow, Rajendra

PY - 1995/1/1

Y1 - 1995/1/1

N2 - A detailed restriction map of the murine TGF-β1 locus (encoding transforming growth factor β1) was established and the precise junctional sequences of its seven exons and corresponding introns were elucidated. While the exons ranged in size from 78 to 357 bp, the introns ranged from about 1 to 6.5 kb. The promoter-proximal segment contains many putative regulatory motifs which may dictate TGF-βl gene transcription in response to varied pathophysiological stimuli.

AB - A detailed restriction map of the murine TGF-β1 locus (encoding transforming growth factor β1) was established and the precise junctional sequences of its seven exons and corresponding introns were elucidated. While the exons ranged in size from 78 to 357 bp, the introns ranged from about 1 to 6.5 kb. The promoter-proximal segment contains many putative regulatory motifs which may dictate TGF-βl gene transcription in response to varied pathophysiological stimuli.

UR - http://www.scopus.com/inward/record.url?scp=0028799856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028799856&partnerID=8YFLogxK

U2 - 10.1016/0378-1119(95)00460-N

DO - 10.1016/0378-1119(95)00460-N

M3 - Article

VL - 165

SP - 325

EP - 326

JO - Gene

JF - Gene

SN - 0378-1119

IS - 2

ER -