Molecular pathogenesis of pneumococcal pneumonia.

Jonathan Mccullers, E. I. Tuomanen

Research output: Contribution to journalReview article

68 Citations (Scopus)

Abstract

The past two decades have witnessed an explosion of data on the molecular pathogenesis of pneumonia caused by Streptococcus pneumoniae, one of the most important pathogens currently plaguing man. Identification and functional analysis of genes and their proteins, elucidation of mechanisms involved in adherence, colonization, inflammation, and invasion, and an understanding of interactions with the host and with external factors have provided knowledge that can be used to attack this organism with small molecule or vaccine based strategies. Study of the pneumococcus has also led to insights into other pathogens that share a unique spectrum of respiratory disease. In this review we will discuss recent advances in our understanding of the pathogenesis of pneumonia due to S. pneumoniae, highlighting emerging themes common to other organisms such as Haemophilus influenzae and Neisseria meningitidis.

Original languageEnglish (US)
JournalFrontiers in bioscience : a journal and virtual library
Volume6
StatePublished - Jan 1 2001

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Pneumococcal Pneumonia
Pathogens
Streptococcus pneumoniae
Pulmonary diseases
Functional analysis
Pneumonia
Explosions
Neisseria meningitidis
Vaccines
Haemophilus influenzae
Molecules
Inflammation
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Molecular pathogenesis of pneumococcal pneumonia. / Mccullers, Jonathan; Tuomanen, E. I.

In: Frontiers in bioscience : a journal and virtual library, Vol. 6, 01.01.2001.

Research output: Contribution to journalReview article

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