Molecular pathology and diagnostics of colorectal cancer

Rodney E. Shackelford, Aejaz Nasir, Ardeshir Hakam, David Shibata, Timothy Yeatman, Domenico Coppola

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Colorectal carcinoma (CRC) is the third most common malignancy in the United States and is the second leading cause of cancer deaths. Over the past 20 years, our knowledge of this CRC carcinogenesis has enormously increased; presently, several molecular diagnostic tests are commonly employed to analyze stage IV CRC and familiar CRC syndromes to determine treatment options and CRC inheritance and risk. More recently the number of CRC diagnostic tests has enormously expanded as our knowledge of CRC carcinogenesis has increased. Here, we review the standard tests employed in CRC, such as KRAS and Braf analyses, and also include less commonly employed tests related to familiar CRC and microsatellite instability. Last, we focus on possible future CRC genetic tests and testing modalities, focusing on techniques such as microarray and mass spectrophotometry.

Original languageEnglish (US)
Title of host publicationMolecular Pathology and Diagnostics of Cancer
PublisherSpringer Netherlands
Pages119-175
Number of pages57
ISBN (Electronic)9789400771925
ISBN (Print)9789400771918
DOIs
StatePublished - Jan 1 2014

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Molecular Pathology
Colorectal Neoplasms
Routine Diagnostic Tests
Carcinogenesis
Microsatellite Instability
Spectrophotometry
Genetic Testing
Cause of Death
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Shackelford, R. E., Nasir, A., Hakam, A., Shibata, D., Yeatman, T., & Coppola, D. (2014). Molecular pathology and diagnostics of colorectal cancer. In Molecular Pathology and Diagnostics of Cancer (pp. 119-175). Springer Netherlands. https://doi.org/10.1007/978-94-007-7192-5_5

Molecular pathology and diagnostics of colorectal cancer. / Shackelford, Rodney E.; Nasir, Aejaz; Hakam, Ardeshir; Shibata, David; Yeatman, Timothy; Coppola, Domenico.

Molecular Pathology and Diagnostics of Cancer. Springer Netherlands, 2014. p. 119-175.

Research output: Chapter in Book/Report/Conference proceedingChapter

Shackelford, RE, Nasir, A, Hakam, A, Shibata, D, Yeatman, T & Coppola, D 2014, Molecular pathology and diagnostics of colorectal cancer. in Molecular Pathology and Diagnostics of Cancer. Springer Netherlands, pp. 119-175. https://doi.org/10.1007/978-94-007-7192-5_5
Shackelford RE, Nasir A, Hakam A, Shibata D, Yeatman T, Coppola D. Molecular pathology and diagnostics of colorectal cancer. In Molecular Pathology and Diagnostics of Cancer. Springer Netherlands. 2014. p. 119-175 https://doi.org/10.1007/978-94-007-7192-5_5
Shackelford, Rodney E. ; Nasir, Aejaz ; Hakam, Ardeshir ; Shibata, David ; Yeatman, Timothy ; Coppola, Domenico. / Molecular pathology and diagnostics of colorectal cancer. Molecular Pathology and Diagnostics of Cancer. Springer Netherlands, 2014. pp. 119-175
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