Molecular pathways and animal models of cardiomyopathies

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cardiomyopathies are a heterogeneous group of disorders of heart muscle that ultimately result in congestive heart failure (CHF), sudden cardiac death, and/or arrhythmias. Contraction of heart muscle is the prime force for efficient pumping of the blood during systole, and relaxation is main force that collects a sufficient volume of blood during diastole, preparing ventricles for next efficient contraction. Efficient contraction and relaxation is maintained by cadre of intracellular and intercellular molecular signaling though paracrine communication. However, persistent unfavorable imbalance of these molecular pathways results in systolic and/or diastolic dysfunction leading to failure of the heart to maintain hemodynamic balance. Rapid progress in genetics as well as in molecular and cellular biology over the past 25 years has greatly improved the understanding of pathogenic signaling pathways in inherited cardiomyopathies. This chapter will focus on intracellular and intercellular molecular signaling pathways that are activated by a genetic insult in cardiomyocytes to maintain tissue and organ level regulation and resultant cardiac remodeling in certain forms of cardiomyopathies. In addition, animal models of different clinical forms of human cardiomyopathies with summaries of triggered key molecules and signaling pathways will be described.

Original languageEnglish (US)
Title of host publicationCongenital Heart Diseases
Subtitle of host publicationThe Broken Heart: Clinical Features, Human Genetics and Molecular Pathways
PublisherSpringer-Verlag Wien
Pages687-711
Number of pages25
ISBN (Electronic)9783709118832
ISBN (Print)9783709118825
DOIs
StatePublished - Jan 1 2015

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Molecular Models
Cardiomyopathies
Animals
Animal Models
Muscle
Myocardium
Blood
Heart Failure
Paracrine Communication
Cytology
Molecular biology
Diastole
Systole
Sudden Cardiac Death
Hemodynamics
Blood Volume
Cardiac Myocytes
Cell Biology
Cardiac Arrhythmias
Molecular Biology

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Purevjav, E. (2015). Molecular pathways and animal models of cardiomyopathies. In Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways (pp. 687-711). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-1883-2_60

Molecular pathways and animal models of cardiomyopathies. / Purevjav, Enkhsaikhan.

Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways. Springer-Verlag Wien, 2015. p. 687-711.

Research output: Chapter in Book/Report/Conference proceedingChapter

Purevjav, E 2015, Molecular pathways and animal models of cardiomyopathies. in Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways. Springer-Verlag Wien, pp. 687-711. https://doi.org/10.1007/978-3-7091-1883-2_60
Purevjav E. Molecular pathways and animal models of cardiomyopathies. In Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways. Springer-Verlag Wien. 2015. p. 687-711 https://doi.org/10.1007/978-3-7091-1883-2_60
Purevjav, Enkhsaikhan. / Molecular pathways and animal models of cardiomyopathies. Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways. Springer-Verlag Wien, 2015. pp. 687-711
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