Monkey globus pallidus external segment neurons projecting to the neostriatum

Hitoshi Kita, Hironobu Tokuno, Atsushi Nambu

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Experiments were performed to assess the number and parvalbumin (PV) immunoreactivity of neurons participating in the pallidostriatal projection in macaque monkeys. Injection of WGA-HRP into the right caudate nucleus and the left putamen of a Macaca mulatta and a M. fuscata labeled a large number of the globus pallidus external segment (GPe) neurons. Counting neurons labeled with WGA-HRP and those stained with neuronal markers indicated that ~30% of GPe neurons project to neostriatum. Approximately 2/3 of the pallidostriatal neurons are PV-immunoreactive. This study revealed that a significant number of primate GPe PV immunoreactive neurons project to the neostriatum, and suggest that the pallidostriatal projection should be taken into account in the analysis of functional roles of the basal ganglia circuitry.

Original languageEnglish (US)
Pages (from-to)1467-1472
Number of pages6
JournalNeuroReport
Volume10
Issue number7
DOIs
StatePublished - May 14 1999

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Neostriatum
Globus Pallidus
Haplorhini
Neurons
Parvalbumins
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
Caudate Nucleus
Putamen
Macaca
Basal Ganglia
Macaca mulatta
Primates
Injections

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Monkey globus pallidus external segment neurons projecting to the neostriatum. / Kita, Hitoshi; Tokuno, Hironobu; Nambu, Atsushi.

In: NeuroReport, Vol. 10, No. 7, 14.05.1999, p. 1467-1472.

Research output: Contribution to journalArticle

Kita, Hitoshi ; Tokuno, Hironobu ; Nambu, Atsushi. / Monkey globus pallidus external segment neurons projecting to the neostriatum. In: NeuroReport. 1999 ; Vol. 10, No. 7. pp. 1467-1472.
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