Monoamine oxidase A (MAOA) genotype predicts greater aggression through impulsive reactivity to negative affect

David S. Chester, C. Nathan DeWall, Karen Derefinko, Steven Estus, Jessica R. Peters, Donald R. Lynam, Yang Jiang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Low functioning MAOA genotypes have been reliably linked to increased reactive aggression, yet the psychological mechanisms of this effect remain largely unknown. The low functioning MAOA genotype's established link to diminished inhibition and greater reactivity to conditions of negative affect suggest that negative urgency, the tendency to act impulsively in the context of negative affect, may fill this mediating role. Such MAOA carriers may have higher negative urgency, which may in turn predict greater aggressive responses to provocation. To test these hypotheses, 277 female and male participants were genotyped for an MAOA SNP yet to be linked to aggression (rs1465108), and then reported their negative urgency and past aggressive behavior. We replicated the effect of the low functioning MAOA genotype on heightened aggression, which was mediated by greater negative urgency. These results suggest that disrupted serotonergic systems predispose individuals towards aggressive behavior by increasing impulsive reactivity to negative affect.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalBehavioural Brain Research
Volume283
DOIs
StatePublished - Apr 5 2015
Externally publishedYes

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Monoamine Oxidase
Aggression
Genotype
Impulsive Behavior
Single Nucleotide Polymorphism
Psychology

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Monoamine oxidase A (MAOA) genotype predicts greater aggression through impulsive reactivity to negative affect. / Chester, David S.; DeWall, C. Nathan; Derefinko, Karen; Estus, Steven; Peters, Jessica R.; Lynam, Donald R.; Jiang, Yang.

In: Behavioural Brain Research, Vol. 283, 05.04.2015, p. 97-101.

Research output: Contribution to journalArticle

Chester, David S. ; DeWall, C. Nathan ; Derefinko, Karen ; Estus, Steven ; Peters, Jessica R. ; Lynam, Donald R. ; Jiang, Yang. / Monoamine oxidase A (MAOA) genotype predicts greater aggression through impulsive reactivity to negative affect. In: Behavioural Brain Research. 2015 ; Vol. 283. pp. 97-101.
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