Morphine and rapid disease progression in nonhuman primate model of AIDS

Inverse correlation between disease progression and virus evolution

Vanessa Rivera-Amill, Peter S. Silverstein, Richard J. Noel, Santosh Kumar, Anil Kumar

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

HIV and simian immunodeficiency virus (SIV) have a formidable capacity for mutation and adaptation, a characteristic that has contributed to the extensive genetic variability. Evolutionary pressures imposed within the host and the viral capacity to mutate lead to the generation of such variants. To date, very little information is available regarding the evolution of HIV with drug abuse as a cofounding factor. Using our macaque model of drug dependency and AIDS, we have investigated the dynamics of SIV mutations in the genes tat, vpr, envelope, and nef. The results presented in this review, from our laboratory and others, contribute to the overall understanding of how drugs of abuse might influence immune selective pressure contribution to variation in different SIV genes. Additionally, the studies presented could help enlighten the development of HIV vaccines that take into consideration viral diversity.

Original languageEnglish (US)
Pages (from-to)122-132
Number of pages11
JournalJournal of Neuroimmune Pharmacology
Volume5
Issue number1
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

Fingerprint

Simian Immunodeficiency Virus
Morphine
Primates
Disease Progression
Acquired Immunodeficiency Syndrome
Viruses
tat Genes
HIV
vpr Genes
Anti-HIV Agents
AIDS Vaccines
Mutation
Macaca
Street Drugs
Substance-Related Disorders
Pressure
Genes

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Morphine and rapid disease progression in nonhuman primate model of AIDS : Inverse correlation between disease progression and virus evolution. / Rivera-Amill, Vanessa; Silverstein, Peter S.; Noel, Richard J.; Kumar, Santosh; Kumar, Anil.

In: Journal of Neuroimmune Pharmacology, Vol. 5, No. 1, 01.03.2010, p. 122-132.

Research output: Contribution to journalReview article

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