Motor abnormalities and changes in the noradrenaline content and the cytoarchitecture of developing cerebellum following X-Irradiation at birth

Laura R. Guelman, Luis M. Zieher, Hugo Rios, Jose Mayo, Alejandro Dopico

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We have studied the developmental time-course of changes in the noradrenaline (NA) content of cerebellum (CE), cytoarchitecture of the cerebellar cortex, and motor abnormalities induced by the exposure of the cephalic end of rats to a single dose (5 Gy°) of X-irradiation immediately after birth. At all ages examined, i.e., from postnatal (PN) d 5 to 90, CE from exposed animals show a marked atrophy, with an agranular cortex that has lost its layered structure. Purkinje cells are scattered at all depths in the cortex, and their primary dendrite is randomly oriented. The motor syndrome includes dystonia-like movements, a fine tremor, and an ataxic gait. Being progressive, the abnormal movements are evident from PN d 10, and fully developed by d 30. On the other hand, no differences in cerebellar NA content between X-irradiated rats and age-matched nonirradiated controls were detected from PN d 5 to 60. However, at PN d 90 a significant increase in NA content of CE from exposed animals is found when compared to either age-matched controls (+36%, p<0.01), or data from irradiated rats obtained at PN d 5 to 60 (p<0.01). These results indicate a temporal dissociation between the motor and cytoarchitectural abnormalities and the increase in cerebellar NA content produced by a single dose of X-rays at birth. The late increase in cerebellar NA content might represent a compensatory response of noradrenergic terminals to an altered information flow out of the cerebellar cortex induced by the ionizing noxa.

Original languageEnglish (US)
Pages (from-to)45-57
Number of pages13
JournalMolecular and Chemical Neuropathology
Volume20
Issue number1
DOIs
StatePublished - Sep 1 1993
Externally publishedYes

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Cerebellum
Norepinephrine
Parturition
Cerebellar Cortex
Noxae
Dystonia
Purkinje Cells
Dyskinesias
Tremor
Dendrites
Gait
Atrophy
Head
X-Rays

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology

Cite this

Motor abnormalities and changes in the noradrenaline content and the cytoarchitecture of developing cerebellum following X-Irradiation at birth. / Guelman, Laura R.; Zieher, Luis M.; Rios, Hugo; Mayo, Jose; Dopico, Alejandro.

In: Molecular and Chemical Neuropathology, Vol. 20, No. 1, 01.09.1993, p. 45-57.

Research output: Contribution to journalArticle

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