mRNA and protein levels for GABA Aα4, α5, β1 and GABABR1 receptors are altered in brains from subjects with autism

S. Hossein Fatemi, Teri J. Reutiman, Timothy D. Folsom, Robert Rooney, Diven H. Patel, Paul D. Thuras

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

We have shown altered expression of gammaaminobutyric acid A (GABA A) and gamma-aminobutyric acid B (GABA B) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABA A subunits previously associated with autism (GABRα4; GABRα5; GABRβ1). Three GABA receptor subunitsdemonstrated mRNA and protein level concordance in superior frontal cortex (GABRα4, GABRα5, GABRβ1) and one demonstrated concordance in cerebellum (GABBR1). These results provide further evidence of impairment of GABAergic signaling in autism.

Original languageEnglish (US)
Pages (from-to)743-750
Number of pages8
JournalJournal of Autism and Developmental Disorders
Volume40
Issue number6
DOIs
StatePublished - Jun 1 2010
Externally publishedYes

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Autistic Disorder
gamma-Aminobutyric Acid
GABA Receptors
Messenger RNA
Brain
Proteins
Acids
Frontal Lobe
Cerebellum
Western Blotting
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology

Cite this

mRNA and protein levels for GABA Aα4, α5, β1 and GABABR1 receptors are altered in brains from subjects with autism. / Fatemi, S. Hossein; Reutiman, Teri J.; Folsom, Timothy D.; Rooney, Robert; Patel, Diven H.; Thuras, Paul D.

In: Journal of Autism and Developmental Disorders, Vol. 40, No. 6, 01.06.2010, p. 743-750.

Research output: Contribution to journalArticle

Fatemi, S. Hossein ; Reutiman, Teri J. ; Folsom, Timothy D. ; Rooney, Robert ; Patel, Diven H. ; Thuras, Paul D. / mRNA and protein levels for GABA Aα4, α5, β1 and GABABR1 receptors are altered in brains from subjects with autism. In: Journal of Autism and Developmental Disorders. 2010 ; Vol. 40, No. 6. pp. 743-750.
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AU - Thuras, Paul D.

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