Mucin 13

Structure, function, and potential roles in cancer pathogenesis

Diane M. Maher, Brij K. Gupta, Satoshi Nagata, Meena Jaggi, Subhash Chauhan

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

Mucin 13 (MUC13) is a high-molecular-weight transmembrane glycoprotein that is frequently and aberrantly expressed in a variety of epithelial carcinomas, including gastric, colorectal, and ovarian cancers. On the basis of the high expression of MUC13 in cancer cells as well as recent laboratory findings suggesting a malignant phenotype of MUC13-transfected cell lines, the oncogenic potential of MUC13 has emerged. The various functional domains of MUC13 may confer oncogenic potential to MUC13. For example, the bulky extracellular domain with extensive modification with glycan chains may prevent cell-cell and cell-extracellular matrix binding whereas the cytoplasmic tail containing serine and tyrosine residues for potential phosphorylation may participate in cell signaling. MUC13 exhibits the characteristics suitable as an early marker for cancer screening and presents a promising target for antibody-guided targeted therapy.

Original languageEnglish (US)
Pages (from-to)531-537
Number of pages7
JournalMolecular Cancer Research
Volume9
Issue number5
DOIs
StatePublished - May 1 2011

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Mucins
Neoplasms
Early Detection of Cancer
Ovarian Neoplasms
Serine
Stomach Neoplasms
Extracellular Matrix
Polysaccharides
Tyrosine
Colorectal Neoplasms
Glycoproteins
Molecular Weight
Phosphorylation
Carcinoma
Phenotype
Cell Line
Antibodies

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Oncology
  • Cancer Research

Cite this

Mucin 13 : Structure, function, and potential roles in cancer pathogenesis. / Maher, Diane M.; Gupta, Brij K.; Nagata, Satoshi; Jaggi, Meena; Chauhan, Subhash.

In: Molecular Cancer Research, Vol. 9, No. 5, 01.05.2011, p. 531-537.

Research output: Contribution to journalReview article

Maher, Diane M. ; Gupta, Brij K. ; Nagata, Satoshi ; Jaggi, Meena ; Chauhan, Subhash. / Mucin 13 : Structure, function, and potential roles in cancer pathogenesis. In: Molecular Cancer Research. 2011 ; Vol. 9, No. 5. pp. 531-537.
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