Multicenter private practice comparison of tripamide and hydrochlorothiazide in the treatment of hypertension.

E. T. Bope, R. C. Adams, Susan Brewer, C. B. Cairns, N. R. Fosnaugh, P. C. Leidheiser, C. W. Platt, J. S. Polsley, R. R. Romaker, S. D. Scarbrough

Research output: Contribution to journalArticle

Abstract

One hundred fifty-nine patients with essential hypertension were randomly assigned to take 10 mg of tripamide or 50 mg of hydrochlorothiazide once a day for 12 weeks. Both drugs were equally effective in lowering both systolic and diastolic blood pressure in the supine (6/5 vs. 5/5 mm Hg) and standing (8/5 vs 7/6 mm Hg) positions. Tripamide had less effect on serum potassium (0.2 vs. 0.6 mEq/L decrease) and serum uric acid (0.7 vs. 1.2 mg/dL increase) than hydrochlorothiazide. The addition of propranolol to either drug produced a further reduction in blood pressure. The overall incidence and spectrum of adverse reactions were the same for both drugs.

Original languageEnglish (US)
Pages (from-to)197-204
Number of pages8
JournalThe Family practice research journal
Volume7
Issue number4
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Hydrochlorothiazide
Private Practice
Blood Pressure
Hypertension
Pharmaceutical Preparations
Uric Acid
Serum
Propranolol
Potassium
Therapeutics
Incidence
tripamide

Cite this

Bope, E. T., Adams, R. C., Brewer, S., Cairns, C. B., Fosnaugh, N. R., Leidheiser, P. C., ... Scarbrough, S. D. (1988). Multicenter private practice comparison of tripamide and hydrochlorothiazide in the treatment of hypertension. The Family practice research journal, 7(4), 197-204.

Multicenter private practice comparison of tripamide and hydrochlorothiazide in the treatment of hypertension. / Bope, E. T.; Adams, R. C.; Brewer, Susan; Cairns, C. B.; Fosnaugh, N. R.; Leidheiser, P. C.; Platt, C. W.; Polsley, J. S.; Romaker, R. R.; Scarbrough, S. D.

In: The Family practice research journal, Vol. 7, No. 4, 01.01.1988, p. 197-204.

Research output: Contribution to journalArticle

Bope, ET, Adams, RC, Brewer, S, Cairns, CB, Fosnaugh, NR, Leidheiser, PC, Platt, CW, Polsley, JS, Romaker, RR & Scarbrough, SD 1988, 'Multicenter private practice comparison of tripamide and hydrochlorothiazide in the treatment of hypertension.', The Family practice research journal, vol. 7, no. 4, pp. 197-204.
Bope, E. T. ; Adams, R. C. ; Brewer, Susan ; Cairns, C. B. ; Fosnaugh, N. R. ; Leidheiser, P. C. ; Platt, C. W. ; Polsley, J. S. ; Romaker, R. R. ; Scarbrough, S. D. / Multicenter private practice comparison of tripamide and hydrochlorothiazide in the treatment of hypertension. In: The Family practice research journal. 1988 ; Vol. 7, No. 4. pp. 197-204.
@article{ed37649c251443b1ba6d70e9b4141e6d,
title = "Multicenter private practice comparison of tripamide and hydrochlorothiazide in the treatment of hypertension.",
abstract = "One hundred fifty-nine patients with essential hypertension were randomly assigned to take 10 mg of tripamide or 50 mg of hydrochlorothiazide once a day for 12 weeks. Both drugs were equally effective in lowering both systolic and diastolic blood pressure in the supine (6/5 vs. 5/5 mm Hg) and standing (8/5 vs 7/6 mm Hg) positions. Tripamide had less effect on serum potassium (0.2 vs. 0.6 mEq/L decrease) and serum uric acid (0.7 vs. 1.2 mg/dL increase) than hydrochlorothiazide. The addition of propranolol to either drug produced a further reduction in blood pressure. The overall incidence and spectrum of adverse reactions were the same for both drugs.",
author = "Bope, {E. T.} and Adams, {R. C.} and Susan Brewer and Cairns, {C. B.} and Fosnaugh, {N. R.} and Leidheiser, {P. C.} and Platt, {C. W.} and Polsley, {J. S.} and Romaker, {R. R.} and Scarbrough, {S. D.}",
year = "1988",
month = "1",
day = "1",
language = "English (US)",
volume = "7",
pages = "197--204",
journal = "The Family practice research journal",
issn = "0270-2304",
number = "4",

}

TY - JOUR

T1 - Multicenter private practice comparison of tripamide and hydrochlorothiazide in the treatment of hypertension.

AU - Bope, E. T.

AU - Adams, R. C.

AU - Brewer, Susan

AU - Cairns, C. B.

AU - Fosnaugh, N. R.

AU - Leidheiser, P. C.

AU - Platt, C. W.

AU - Polsley, J. S.

AU - Romaker, R. R.

AU - Scarbrough, S. D.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - One hundred fifty-nine patients with essential hypertension were randomly assigned to take 10 mg of tripamide or 50 mg of hydrochlorothiazide once a day for 12 weeks. Both drugs were equally effective in lowering both systolic and diastolic blood pressure in the supine (6/5 vs. 5/5 mm Hg) and standing (8/5 vs 7/6 mm Hg) positions. Tripamide had less effect on serum potassium (0.2 vs. 0.6 mEq/L decrease) and serum uric acid (0.7 vs. 1.2 mg/dL increase) than hydrochlorothiazide. The addition of propranolol to either drug produced a further reduction in blood pressure. The overall incidence and spectrum of adverse reactions were the same for both drugs.

AB - One hundred fifty-nine patients with essential hypertension were randomly assigned to take 10 mg of tripamide or 50 mg of hydrochlorothiazide once a day for 12 weeks. Both drugs were equally effective in lowering both systolic and diastolic blood pressure in the supine (6/5 vs. 5/5 mm Hg) and standing (8/5 vs 7/6 mm Hg) positions. Tripamide had less effect on serum potassium (0.2 vs. 0.6 mEq/L decrease) and serum uric acid (0.7 vs. 1.2 mg/dL increase) than hydrochlorothiazide. The addition of propranolol to either drug produced a further reduction in blood pressure. The overall incidence and spectrum of adverse reactions were the same for both drugs.

UR - http://www.scopus.com/inward/record.url?scp=0024033422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024033422&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 197

EP - 204

JO - The Family practice research journal

JF - The Family practice research journal

SN - 0270-2304

IS - 4

ER -