Multilevel cervical disconnection syndrome: Initial description, embryogenesis, and management: Report of two cases

Paul Klimo, Richard C.E. Anderson, Douglas L. Brockmeyer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Two cases of a previously undescribed cervical spinal anomaly distinct from cervical spondylolysis are presented. The authors report the first detailed description of a congenital vertebral anomaly characterized by multilevel cervical spondylolysis, sagittal deformity, and spinal cord compression. The sine qua non of the condition is a lack of communication between the anterior and posterior columns of the cervical spinal canal, which may occur over several vertebral levels. A kyphotic deformity of the anterior column occurs, whereas the posterior column may have relatively normal alignment. The underlying biomechanical stresses caused by the anterior-posterior column disconnection result in spinal instability and progressive kyphotic deformity, often to a profound degree. Two children, 2 and 3 years of age, presented with congenital multilevel disconnection and myelopathy. In the first stage of treatment, each underwent an anterior decompression, reduction, and reconstruction of the involved segments. This was followed by posterior stabilization and fusion as a separate procedure. In both patients, the myelopathy improved and a solid, circumferential fusion was achieved. The authors' success in treating these patients indicates that management of these conditions can be based on the principles of deformity correction, spinal cord decompression, and combined anterior-posterior arthrodesis.

Original languageEnglish (US)
Pages (from-to)181-187
Number of pages7
JournalJournal of neurosurgery
Volume104 PEDIATRICS
Issue numberSUPPL. 3
StatePublished - Mar 1 2006

Fingerprint

Spondylolysis
Spinal Cord Diseases
Decompression
Embryonic Development
Spinal Cord Compression
Spinal Canal
Arthrodesis
Spinal Cord
Communication
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Multilevel cervical disconnection syndrome : Initial description, embryogenesis, and management: Report of two cases. / Klimo, Paul; Anderson, Richard C.E.; Brockmeyer, Douglas L.

In: Journal of neurosurgery, Vol. 104 PEDIATRICS, No. SUPPL. 3, 01.03.2006, p. 181-187.

Research output: Contribution to journalArticle

Klimo, Paul ; Anderson, Richard C.E. ; Brockmeyer, Douglas L. / Multilevel cervical disconnection syndrome : Initial description, embryogenesis, and management: Report of two cases. In: Journal of neurosurgery. 2006 ; Vol. 104 PEDIATRICS, No. SUPPL. 3. pp. 181-187.
@article{b382e15ebda44a0eb4b4d5ba5951dde3,
title = "Multilevel cervical disconnection syndrome: Initial description, embryogenesis, and management: Report of two cases",
abstract = "Two cases of a previously undescribed cervical spinal anomaly distinct from cervical spondylolysis are presented. The authors report the first detailed description of a congenital vertebral anomaly characterized by multilevel cervical spondylolysis, sagittal deformity, and spinal cord compression. The sine qua non of the condition is a lack of communication between the anterior and posterior columns of the cervical spinal canal, which may occur over several vertebral levels. A kyphotic deformity of the anterior column occurs, whereas the posterior column may have relatively normal alignment. The underlying biomechanical stresses caused by the anterior-posterior column disconnection result in spinal instability and progressive kyphotic deformity, often to a profound degree. Two children, 2 and 3 years of age, presented with congenital multilevel disconnection and myelopathy. In the first stage of treatment, each underwent an anterior decompression, reduction, and reconstruction of the involved segments. This was followed by posterior stabilization and fusion as a separate procedure. In both patients, the myelopathy improved and a solid, circumferential fusion was achieved. The authors' success in treating these patients indicates that management of these conditions can be based on the principles of deformity correction, spinal cord decompression, and combined anterior-posterior arthrodesis.",
author = "Paul Klimo and Anderson, {Richard C.E.} and Brockmeyer, {Douglas L.}",
year = "2006",
month = "3",
day = "1",
language = "English (US)",
volume = "104 PEDIATRICS",
pages = "181--187",
journal = "Journal of Neurosurgery",
issn = "0022-3085",
publisher = "American Association of Neurological Surgeons",
number = "SUPPL. 3",

}

TY - JOUR

T1 - Multilevel cervical disconnection syndrome

T2 - Initial description, embryogenesis, and management: Report of two cases

AU - Klimo, Paul

AU - Anderson, Richard C.E.

AU - Brockmeyer, Douglas L.

PY - 2006/3/1

Y1 - 2006/3/1

N2 - Two cases of a previously undescribed cervical spinal anomaly distinct from cervical spondylolysis are presented. The authors report the first detailed description of a congenital vertebral anomaly characterized by multilevel cervical spondylolysis, sagittal deformity, and spinal cord compression. The sine qua non of the condition is a lack of communication between the anterior and posterior columns of the cervical spinal canal, which may occur over several vertebral levels. A kyphotic deformity of the anterior column occurs, whereas the posterior column may have relatively normal alignment. The underlying biomechanical stresses caused by the anterior-posterior column disconnection result in spinal instability and progressive kyphotic deformity, often to a profound degree. Two children, 2 and 3 years of age, presented with congenital multilevel disconnection and myelopathy. In the first stage of treatment, each underwent an anterior decompression, reduction, and reconstruction of the involved segments. This was followed by posterior stabilization and fusion as a separate procedure. In both patients, the myelopathy improved and a solid, circumferential fusion was achieved. The authors' success in treating these patients indicates that management of these conditions can be based on the principles of deformity correction, spinal cord decompression, and combined anterior-posterior arthrodesis.

AB - Two cases of a previously undescribed cervical spinal anomaly distinct from cervical spondylolysis are presented. The authors report the first detailed description of a congenital vertebral anomaly characterized by multilevel cervical spondylolysis, sagittal deformity, and spinal cord compression. The sine qua non of the condition is a lack of communication between the anterior and posterior columns of the cervical spinal canal, which may occur over several vertebral levels. A kyphotic deformity of the anterior column occurs, whereas the posterior column may have relatively normal alignment. The underlying biomechanical stresses caused by the anterior-posterior column disconnection result in spinal instability and progressive kyphotic deformity, often to a profound degree. Two children, 2 and 3 years of age, presented with congenital multilevel disconnection and myelopathy. In the first stage of treatment, each underwent an anterior decompression, reduction, and reconstruction of the involved segments. This was followed by posterior stabilization and fusion as a separate procedure. In both patients, the myelopathy improved and a solid, circumferential fusion was achieved. The authors' success in treating these patients indicates that management of these conditions can be based on the principles of deformity correction, spinal cord decompression, and combined anterior-posterior arthrodesis.

UR - http://www.scopus.com/inward/record.url?scp=33645746919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645746919&partnerID=8YFLogxK

M3 - Article

C2 - 16572635

AN - SCOPUS:33645746919

VL - 104 PEDIATRICS

SP - 181

EP - 187

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

SN - 0022-3085

IS - SUPPL. 3

ER -