Multimodality neuroimaging evaluation improves the detection of subtle cortical dysplasia in seizure patients

Wenbo Zhang, Panagiotis G. Simos, Hideaki Ishibashi, James Wheless, Eduardo M. Castillo, Howard L. Kim, James E. Baumgartner, Shirin Sarkari, Andrew Papanicolaou

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The purpose of this study is to investigate if multimodality neuroimaging evaluation increases the detection of subtle focal cortical dysplasia as part of an epilepsy surgery evaluation. Three patients with normal magnetic resonance imaging and histopathological findings of focal cortical dysplasia were reviewed. Their magnetoencephalography recordings were performed on whole-head magnetoencephalography system. Magnetic resonance images were re-evaluated with special inspection in limited regions guided by magnetoencephalography spike localization. Two patients had ictal and interictal single photon emission computed tomography study after administration of Tc99m ECD. In two patients we found tiny focal abnormalities including slightly increased cortical thickness and blurred gray-white matter junction at the locations of interictal events after re-evaluation of the MR images indicating focal cortical dysplasia. The third patient showed focal atrophic change. All patients are seizure free after surgery. Both ictal and interictal single photon emission computed tomography showed hyperperfusion in the dysplastic cortex regions. Multimodality neuroimaging study can improve the detection of focal cortical dysplasia. Normal magnetic resonance images should be re-evaluated for subtle signs of focal cortical dysplasia especially when magnetoencephalography recording demonstrate focal epileptic discharges.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalNeurological Research
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2003

Fingerprint

Malformations of Cortical Development
Magnetoencephalography
Neuroimaging
Seizures
Single-Photon Emission-Computed Tomography
Magnetic Resonance Spectroscopy
Stroke
Epilepsy
Head
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Multimodality neuroimaging evaluation improves the detection of subtle cortical dysplasia in seizure patients. / Zhang, Wenbo; Simos, Panagiotis G.; Ishibashi, Hideaki; Wheless, James; Castillo, Eduardo M.; Kim, Howard L.; Baumgartner, James E.; Sarkari, Shirin; Papanicolaou, Andrew.

In: Neurological Research, Vol. 25, No. 1, 01.01.2003, p. 53-57.

Research output: Contribution to journalArticle

Zhang, W, Simos, PG, Ishibashi, H, Wheless, J, Castillo, EM, Kim, HL, Baumgartner, JE, Sarkari, S & Papanicolaou, A 2003, 'Multimodality neuroimaging evaluation improves the detection of subtle cortical dysplasia in seizure patients', Neurological Research, vol. 25, no. 1, pp. 53-57. https://doi.org/10.1179/016164103101201111
Zhang, Wenbo ; Simos, Panagiotis G. ; Ishibashi, Hideaki ; Wheless, James ; Castillo, Eduardo M. ; Kim, Howard L. ; Baumgartner, James E. ; Sarkari, Shirin ; Papanicolaou, Andrew. / Multimodality neuroimaging evaluation improves the detection of subtle cortical dysplasia in seizure patients. In: Neurological Research. 2003 ; Vol. 25, No. 1. pp. 53-57.
@article{11a7edaa751140bf847830ff0ed6c30c,
title = "Multimodality neuroimaging evaluation improves the detection of subtle cortical dysplasia in seizure patients",
abstract = "The purpose of this study is to investigate if multimodality neuroimaging evaluation increases the detection of subtle focal cortical dysplasia as part of an epilepsy surgery evaluation. Three patients with normal magnetic resonance imaging and histopathological findings of focal cortical dysplasia were reviewed. Their magnetoencephalography recordings were performed on whole-head magnetoencephalography system. Magnetic resonance images were re-evaluated with special inspection in limited regions guided by magnetoencephalography spike localization. Two patients had ictal and interictal single photon emission computed tomography study after administration of Tc99m ECD. In two patients we found tiny focal abnormalities including slightly increased cortical thickness and blurred gray-white matter junction at the locations of interictal events after re-evaluation of the MR images indicating focal cortical dysplasia. The third patient showed focal atrophic change. All patients are seizure free after surgery. Both ictal and interictal single photon emission computed tomography showed hyperperfusion in the dysplastic cortex regions. Multimodality neuroimaging study can improve the detection of focal cortical dysplasia. Normal magnetic resonance images should be re-evaluated for subtle signs of focal cortical dysplasia especially when magnetoencephalography recording demonstrate focal epileptic discharges.",
author = "Wenbo Zhang and Simos, {Panagiotis G.} and Hideaki Ishibashi and James Wheless and Castillo, {Eduardo M.} and Kim, {Howard L.} and Baumgartner, {James E.} and Shirin Sarkari and Andrew Papanicolaou",
year = "2003",
month = "1",
day = "1",
doi = "10.1179/016164103101201111",
language = "English (US)",
volume = "25",
pages = "53--57",
journal = "Neurological Research",
issn = "0161-6412",
publisher = "Maney Publishing",
number = "1",

}

TY - JOUR

T1 - Multimodality neuroimaging evaluation improves the detection of subtle cortical dysplasia in seizure patients

AU - Zhang, Wenbo

AU - Simos, Panagiotis G.

AU - Ishibashi, Hideaki

AU - Wheless, James

AU - Castillo, Eduardo M.

AU - Kim, Howard L.

AU - Baumgartner, James E.

AU - Sarkari, Shirin

AU - Papanicolaou, Andrew

PY - 2003/1/1

Y1 - 2003/1/1

N2 - The purpose of this study is to investigate if multimodality neuroimaging evaluation increases the detection of subtle focal cortical dysplasia as part of an epilepsy surgery evaluation. Three patients with normal magnetic resonance imaging and histopathological findings of focal cortical dysplasia were reviewed. Their magnetoencephalography recordings were performed on whole-head magnetoencephalography system. Magnetic resonance images were re-evaluated with special inspection in limited regions guided by magnetoencephalography spike localization. Two patients had ictal and interictal single photon emission computed tomography study after administration of Tc99m ECD. In two patients we found tiny focal abnormalities including slightly increased cortical thickness and blurred gray-white matter junction at the locations of interictal events after re-evaluation of the MR images indicating focal cortical dysplasia. The third patient showed focal atrophic change. All patients are seizure free after surgery. Both ictal and interictal single photon emission computed tomography showed hyperperfusion in the dysplastic cortex regions. Multimodality neuroimaging study can improve the detection of focal cortical dysplasia. Normal magnetic resonance images should be re-evaluated for subtle signs of focal cortical dysplasia especially when magnetoencephalography recording demonstrate focal epileptic discharges.

AB - The purpose of this study is to investigate if multimodality neuroimaging evaluation increases the detection of subtle focal cortical dysplasia as part of an epilepsy surgery evaluation. Three patients with normal magnetic resonance imaging and histopathological findings of focal cortical dysplasia were reviewed. Their magnetoencephalography recordings were performed on whole-head magnetoencephalography system. Magnetic resonance images were re-evaluated with special inspection in limited regions guided by magnetoencephalography spike localization. Two patients had ictal and interictal single photon emission computed tomography study after administration of Tc99m ECD. In two patients we found tiny focal abnormalities including slightly increased cortical thickness and blurred gray-white matter junction at the locations of interictal events after re-evaluation of the MR images indicating focal cortical dysplasia. The third patient showed focal atrophic change. All patients are seizure free after surgery. Both ictal and interictal single photon emission computed tomography showed hyperperfusion in the dysplastic cortex regions. Multimodality neuroimaging study can improve the detection of focal cortical dysplasia. Normal magnetic resonance images should be re-evaluated for subtle signs of focal cortical dysplasia especially when magnetoencephalography recording demonstrate focal epileptic discharges.

UR - http://www.scopus.com/inward/record.url?scp=0037240510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037240510&partnerID=8YFLogxK

U2 - 10.1179/016164103101201111

DO - 10.1179/016164103101201111

M3 - Article

C2 - 12564126

AN - SCOPUS:0037240510

VL - 25

SP - 53

EP - 57

JO - Neurological Research

JF - Neurological Research

SN - 0161-6412

IS - 1

ER -