Multiple adhesins of streptococci

D. L. Hasty, I. Ofek, H. S. Courtney, R. J. Doyle

Research output: Contribution to journalShort survey

189 Citations (Scopus)

Abstract

In summary, the multiple streptococcal adhesins appear to contribute to the overall ability of the organisms to colonize various niches in the upper respiratory tract. They do so by two modes. One involves two distinct adhesive steps, the first of which is readily reversible and requisite in order to pass to the second step, after which adhesion is essentially irreversible. The other depends upon the expression of one or more adhesins that may undergo phase variation, similar to the expression of mannose- sensitive and mannose-resistant adhesins by members of the Enterobacteriaceae (27, 32). It is recognized that the model proposed for streptococcal adhesion does not necessarily resolve all of the issues involved in this complex phenomenon, even for S. sanguis and S. pyogenes. The model does, however, provide an explanation for many observations of adhesion of these species that otherwise are difficult to resolve. Further understanding of adhesion mechanisms must take into account both strain and substratum variation and is not likely to result from simplistic analyses of biochemical or molecular genetic experiments alone. The model also permits the design of experiments needed to delineate further the various activities of multiple adhesins expressed by pathogenic streptococci.

Original languageEnglish (US)
Pages (from-to)2147-2152
Number of pages6
JournalInfection and Immunity
Volume60
Issue number6
StatePublished - 1992

Fingerprint

Mannose
Streptococcus
Molecular Biology
Enterobacteriaceae
Adhesives
Respiratory System

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Hasty, D. L., Ofek, I., Courtney, H. S., & Doyle, R. J. (1992). Multiple adhesins of streptococci. Infection and Immunity, 60(6), 2147-2152.

Multiple adhesins of streptococci. / Hasty, D. L.; Ofek, I.; Courtney, H. S.; Doyle, R. J.

In: Infection and Immunity, Vol. 60, No. 6, 1992, p. 2147-2152.

Research output: Contribution to journalShort survey

Hasty, DL, Ofek, I, Courtney, HS & Doyle, RJ 1992, 'Multiple adhesins of streptococci', Infection and Immunity, vol. 60, no. 6, pp. 2147-2152.
Hasty DL, Ofek I, Courtney HS, Doyle RJ. Multiple adhesins of streptococci. Infection and Immunity. 1992;60(6):2147-2152.
Hasty, D. L. ; Ofek, I. ; Courtney, H. S. ; Doyle, R. J. / Multiple adhesins of streptococci. In: Infection and Immunity. 1992 ; Vol. 60, No. 6. pp. 2147-2152.
@article{28ab6f0e5e1742deaa9eb35cdcca3c2e,
title = "Multiple adhesins of streptococci",
abstract = "In summary, the multiple streptococcal adhesins appear to contribute to the overall ability of the organisms to colonize various niches in the upper respiratory tract. They do so by two modes. One involves two distinct adhesive steps, the first of which is readily reversible and requisite in order to pass to the second step, after which adhesion is essentially irreversible. The other depends upon the expression of one or more adhesins that may undergo phase variation, similar to the expression of mannose- sensitive and mannose-resistant adhesins by members of the Enterobacteriaceae (27, 32). It is recognized that the model proposed for streptococcal adhesion does not necessarily resolve all of the issues involved in this complex phenomenon, even for S. sanguis and S. pyogenes. The model does, however, provide an explanation for many observations of adhesion of these species that otherwise are difficult to resolve. Further understanding of adhesion mechanisms must take into account both strain and substratum variation and is not likely to result from simplistic analyses of biochemical or molecular genetic experiments alone. The model also permits the design of experiments needed to delineate further the various activities of multiple adhesins expressed by pathogenic streptococci.",
author = "Hasty, {D. L.} and I. Ofek and Courtney, {H. S.} and Doyle, {R. J.}",
year = "1992",
language = "English (US)",
volume = "60",
pages = "2147--2152",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "6",

}

TY - JOUR

T1 - Multiple adhesins of streptococci

AU - Hasty, D. L.

AU - Ofek, I.

AU - Courtney, H. S.

AU - Doyle, R. J.

PY - 1992

Y1 - 1992

N2 - In summary, the multiple streptococcal adhesins appear to contribute to the overall ability of the organisms to colonize various niches in the upper respiratory tract. They do so by two modes. One involves two distinct adhesive steps, the first of which is readily reversible and requisite in order to pass to the second step, after which adhesion is essentially irreversible. The other depends upon the expression of one or more adhesins that may undergo phase variation, similar to the expression of mannose- sensitive and mannose-resistant adhesins by members of the Enterobacteriaceae (27, 32). It is recognized that the model proposed for streptococcal adhesion does not necessarily resolve all of the issues involved in this complex phenomenon, even for S. sanguis and S. pyogenes. The model does, however, provide an explanation for many observations of adhesion of these species that otherwise are difficult to resolve. Further understanding of adhesion mechanisms must take into account both strain and substratum variation and is not likely to result from simplistic analyses of biochemical or molecular genetic experiments alone. The model also permits the design of experiments needed to delineate further the various activities of multiple adhesins expressed by pathogenic streptococci.

AB - In summary, the multiple streptococcal adhesins appear to contribute to the overall ability of the organisms to colonize various niches in the upper respiratory tract. They do so by two modes. One involves two distinct adhesive steps, the first of which is readily reversible and requisite in order to pass to the second step, after which adhesion is essentially irreversible. The other depends upon the expression of one or more adhesins that may undergo phase variation, similar to the expression of mannose- sensitive and mannose-resistant adhesins by members of the Enterobacteriaceae (27, 32). It is recognized that the model proposed for streptococcal adhesion does not necessarily resolve all of the issues involved in this complex phenomenon, even for S. sanguis and S. pyogenes. The model does, however, provide an explanation for many observations of adhesion of these species that otherwise are difficult to resolve. Further understanding of adhesion mechanisms must take into account both strain and substratum variation and is not likely to result from simplistic analyses of biochemical or molecular genetic experiments alone. The model also permits the design of experiments needed to delineate further the various activities of multiple adhesins expressed by pathogenic streptococci.

UR - http://www.scopus.com/inward/record.url?scp=0026696227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026696227&partnerID=8YFLogxK

M3 - Short survey

VL - 60

SP - 2147

EP - 2152

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 6

ER -