Murine model of anterior and posterior ocular melanoma

Hans E. Grossniklaus, Brent C. Barron, Matthew Wilson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Iris melanomas are less likely to metastasize than ciliary body or choroidal melanomas. In order to study this difference in metastatic rate, we developed a murine model of anterior chamber (AC) and posterior compartment (PC) melanoma. Eighteen C57BL6 mice were inoculated in the AC (n = 6) or PC (n = 12) with B16F10 melanoma cells and eleven mice were inoculated in the AC (n = 3) or PC (n = 8) with Queens melanoma cells. The animals were sacrificed at 12 to 14 days post inoculation and histologically examined. Results were that 8 of 9 AC tumors and 10 of 20 PC tumors grew. One PC tumor metastasized to the lungs. This model may be used to study anterior versus posterior ocular melanoma differences.

Original languageEnglish (US)
Pages (from-to)399-404
Number of pages6
JournalCurrent Eye Research
Volume14
Issue number5
DOIs
StatePublished - Jan 1 1995

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Melanoma
Anterior Chamber
Neoplasms
Ciliary Body
Iris
Lung

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Murine model of anterior and posterior ocular melanoma. / Grossniklaus, Hans E.; Barron, Brent C.; Wilson, Matthew.

In: Current Eye Research, Vol. 14, No. 5, 01.01.1995, p. 399-404.

Research output: Contribution to journalArticle

Grossniklaus, Hans E. ; Barron, Brent C. ; Wilson, Matthew. / Murine model of anterior and posterior ocular melanoma. In: Current Eye Research. 1995 ; Vol. 14, No. 5. pp. 399-404.
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