Muscle calcium and magnesium content in Duchenne muscular dystrophy

Tulio Bertorini, Syamal Bhattacharya, G. M.A. Palmieri, C. M. Chesney, D. Pifer, B. Baker

Research output: Contribution to journalArticle

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Abstract

Calcium (Ca) and magnesium (Mg) content were determined in muscle of 27 patients with Duchenne muscular dystrophy, 36 with other neuromuscular diseases, and 22 whose muscle biopsy specimens were histochemically normal. Muscle Ca was significantly elevated in all diseases studied but was about 50% higher in Duchenne dystrophy patients (p < 0.0001). Mg was decreased by 44% in Duchenne dystrophy, compared with less striking deficits in other diseases (p < 0.005). In older, nonambulatory Duchenne dystrophy patients, Mg was significantly lower than in younger, ambulatory patients (p < 0.001); muscle Ca was the same in both groups. On the basis of noncollagen nitrogen concentration, muscle Mg depletion could not be attributed solely to reduced muscle mass. These findings strengthen arguments for a role of Ca in the pathogenesis of muscular dystrophy and may implicate Mg depletion as another pathogenetic factor.

Original languageEnglish (US)
Pages (from-to)1088-1092
Number of pages5
JournalNeurology
Volume32
Issue number10
StatePublished - Nov 29 1982

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Duchenne Muscular Dystrophy
Magnesium
Calcium
Muscles
Neuromuscular Diseases
Muscular Dystrophies
Nitrogen
Biopsy

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Bertorini, T., Bhattacharya, S., Palmieri, G. M. A., Chesney, C. M., Pifer, D., & Baker, B. (1982). Muscle calcium and magnesium content in Duchenne muscular dystrophy. Neurology, 32(10), 1088-1092.

Muscle calcium and magnesium content in Duchenne muscular dystrophy. / Bertorini, Tulio; Bhattacharya, Syamal; Palmieri, G. M.A.; Chesney, C. M.; Pifer, D.; Baker, B.

In: Neurology, Vol. 32, No. 10, 29.11.1982, p. 1088-1092.

Research output: Contribution to journalArticle

Bertorini, T, Bhattacharya, S, Palmieri, GMA, Chesney, CM, Pifer, D & Baker, B 1982, 'Muscle calcium and magnesium content in Duchenne muscular dystrophy', Neurology, vol. 32, no. 10, pp. 1088-1092.
Bertorini T, Bhattacharya S, Palmieri GMA, Chesney CM, Pifer D, Baker B. Muscle calcium and magnesium content in Duchenne muscular dystrophy. Neurology. 1982 Nov 29;32(10):1088-1092.
Bertorini, Tulio ; Bhattacharya, Syamal ; Palmieri, G. M.A. ; Chesney, C. M. ; Pifer, D. ; Baker, B. / Muscle calcium and magnesium content in Duchenne muscular dystrophy. In: Neurology. 1982 ; Vol. 32, No. 10. pp. 1088-1092.
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