Mutation screening for the genes causing cardiac arrhythmias.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this chapter, the up-to-date understanding of the molecular basis of disorders causing arrhythmias are outlined. Several arrhythmic disorders have been well described at the molecular level, including the long QT syndromes (LQTS), Brugada syndrome, and polymorphic ventricular tachycardia. The genes identified have been determined using genetic linkage analysis, cloning, and mutation analyses. In the past, cloning was common, but with completion of the Human Genome Project, cloning is now rarely needed. In this chapter, current mutation screening methods, including denaturing high-performance liquid chromatography (DHPLC) and DNA sequencing are described, and the current knowledge gained using these studies is discussed.

Original languageEnglish (US)
Pages (from-to)57-79
Number of pages23
JournalMethods in molecular medicine
Volume126
StatePublished - Jan 1 2006
Externally publishedYes

Fingerprint

Organism Cloning
Cardiac Arrhythmias
Mutation
Brugada Syndrome
Genes
Human Genome Project
Long QT Syndrome
Genetic Linkage
Ventricular Tachycardia
DNA Sequence Analysis
High Pressure Liquid Chromatography

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

Cite this

Mutation screening for the genes causing cardiac arrhythmias. / Towbin, Jeffrey.

In: Methods in molecular medicine, Vol. 126, 01.01.2006, p. 57-79.

Research output: Contribution to journalArticle

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