Mutations spectrum of GNE in hereditary inclusion body myopathy sparing the quadriceps.

Iris Eisenberg, Gil Grabov-Nardini, Hagit Hochner, Mira Korner, Menachem Sadeh, Tulio Bertorini, Kate Bushby, Claudio Castellan, Kevin Felice, Jerry Mendell, Luciano Merlini, Christopher Shilling, Itshak Wirguin, Zohar Argov, Stella Mitrani-Rosenbaum

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Hereditary Inclusion Body Myopathy (HIBM) is a unique group of neuromuscular disorders characterized by adult onset and a typical muscle pathology. We have recently identified the gene encoding for a bifunctional enzyme, UDP-N-acetylglucosamine 2 epimerase/N-acetylmannosamine kinase (GNE), as the mutated gene in the prototype form of the disease presenting quadriceps sparing, particularly common in Middle Eastern Jews. Interestingly, we have identified the homozygous M712T Middle Eastern Jewish mutation also in two unrelated Middle Eastern Moslem families. We have also evaluated the involvement of GNE in several families from worldwide non-Jewish ethnic origins presenting symptoms similar to the Middle Eastern HIBM prototype. A total of 14 GNE mutations were identified (one nonsense and 13 missense), of which six are novel: an homozygous missense mutation in a consanguineous family from Italy and in a non consanguineous family from USA, and distinct compound heterozygotes in families from Germany, Italy, Ireland, Bahamas, USA and East India. This study brings to 17 the number of reported GNE mutations in quadriceps sparing myopathy, occurring either in the epimerase or the kinase domain of the enzyme. The mechanism leading to this unique phenotype still remains to be elucidated.

Original languageEnglish (US)
Number of pages1
JournalHuman mutation
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2003

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Mutation
Italy
Bahamas
Racemases and Epimerases
Jews
Muscular Diseases
Missense Mutation
Enzymes
Heterozygote
Ireland
Genes
Germany
India
Phosphotransferases
Nonaka type Distal myopathy
Pathology
Phenotype
Muscles

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Eisenberg, I., Grabov-Nardini, G., Hochner, H., Korner, M., Sadeh, M., Bertorini, T., ... Mitrani-Rosenbaum, S. (2003). Mutations spectrum of GNE in hereditary inclusion body myopathy sparing the quadriceps. Human mutation, 21(1). https://doi.org/10.1002/humu.9100

Mutations spectrum of GNE in hereditary inclusion body myopathy sparing the quadriceps. / Eisenberg, Iris; Grabov-Nardini, Gil; Hochner, Hagit; Korner, Mira; Sadeh, Menachem; Bertorini, Tulio; Bushby, Kate; Castellan, Claudio; Felice, Kevin; Mendell, Jerry; Merlini, Luciano; Shilling, Christopher; Wirguin, Itshak; Argov, Zohar; Mitrani-Rosenbaum, Stella.

In: Human mutation, Vol. 21, No. 1, 01.01.2003.

Research output: Contribution to journalArticle

Eisenberg, I, Grabov-Nardini, G, Hochner, H, Korner, M, Sadeh, M, Bertorini, T, Bushby, K, Castellan, C, Felice, K, Mendell, J, Merlini, L, Shilling, C, Wirguin, I, Argov, Z & Mitrani-Rosenbaum, S 2003, 'Mutations spectrum of GNE in hereditary inclusion body myopathy sparing the quadriceps.', Human mutation, vol. 21, no. 1. https://doi.org/10.1002/humu.9100
Eisenberg, Iris ; Grabov-Nardini, Gil ; Hochner, Hagit ; Korner, Mira ; Sadeh, Menachem ; Bertorini, Tulio ; Bushby, Kate ; Castellan, Claudio ; Felice, Kevin ; Mendell, Jerry ; Merlini, Luciano ; Shilling, Christopher ; Wirguin, Itshak ; Argov, Zohar ; Mitrani-Rosenbaum, Stella. / Mutations spectrum of GNE in hereditary inclusion body myopathy sparing the quadriceps. In: Human mutation. 2003 ; Vol. 21, No. 1.
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