Mycobacterium chelonae necrotizing pneumonia after allogeneic hematopoietic stem cell transplant

Report of clinical response to treatment with tigecycline

E. Peres, Yasser Khaled, O. I. Krijanovski, S. Mineishi, J. E. Levine, D. R. Kaul, J. Riddell IV

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We present a case of progressive Mycobacterium chelonae ssp. chelonae necrotizing pneumonia after hematopoietic stem cell transplantation (HSCT) in the presence of chronic graft-versus-host disease. The patient failed to respond to standard combination therapy with multiple agents and developed resistance to most drugs over the course of treatment. Tigecycline, a new glycylcycline antimicrobial agent with in vitro activity against M. chelonae, was then used with a clinical response to treatment. To our knowledge, this is the first reported case demonstrating tigecycline to have a degree of clinical effectiveness to treat refractory pulmonary infection with M. chelonae in an HSCT recipient.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalTransplant Infectious Disease
Volume11
Issue number1
DOIs
StatePublished - Feb 1 2009

Fingerprint

Mycobacterium chelonae
Hematopoietic Stem Cells
Hematopoietic Stem Cell Transplantation
Transplants
Graft vs Host Disease
Anti-Infective Agents
Therapeutics
Lung
Infection
Pharmaceutical Preparations
tigecycline
Necrotizing Pneumonia

All Science Journal Classification (ASJC) codes

  • Transplantation
  • Infectious Diseases

Cite this

Mycobacterium chelonae necrotizing pneumonia after allogeneic hematopoietic stem cell transplant : Report of clinical response to treatment with tigecycline. / Peres, E.; Khaled, Yasser; Krijanovski, O. I.; Mineishi, S.; Levine, J. E.; Kaul, D. R.; Riddell IV, J.

In: Transplant Infectious Disease, Vol. 11, No. 1, 01.02.2009, p. 57-63.

Research output: Contribution to journalArticle

Peres, E. ; Khaled, Yasser ; Krijanovski, O. I. ; Mineishi, S. ; Levine, J. E. ; Kaul, D. R. ; Riddell IV, J. / Mycobacterium chelonae necrotizing pneumonia after allogeneic hematopoietic stem cell transplant : Report of clinical response to treatment with tigecycline. In: Transplant Infectious Disease. 2009 ; Vol. 11, No. 1. pp. 57-63.
@article{f1f8d8c49d0945e5b18d4ec03b5e6ffa,
title = "Mycobacterium chelonae necrotizing pneumonia after allogeneic hematopoietic stem cell transplant: Report of clinical response to treatment with tigecycline",
abstract = "We present a case of progressive Mycobacterium chelonae ssp. chelonae necrotizing pneumonia after hematopoietic stem cell transplantation (HSCT) in the presence of chronic graft-versus-host disease. The patient failed to respond to standard combination therapy with multiple agents and developed resistance to most drugs over the course of treatment. Tigecycline, a new glycylcycline antimicrobial agent with in vitro activity against M. chelonae, was then used with a clinical response to treatment. To our knowledge, this is the first reported case demonstrating tigecycline to have a degree of clinical effectiveness to treat refractory pulmonary infection with M. chelonae in an HSCT recipient.",
author = "E. Peres and Yasser Khaled and Krijanovski, {O. I.} and S. Mineishi and Levine, {J. E.} and Kaul, {D. R.} and {Riddell IV}, J.",
year = "2009",
month = "2",
day = "1",
doi = "10.1111/j.1399-3062.2008.00351.x",
language = "English (US)",
volume = "11",
pages = "57--63",
journal = "Transplant Infectious Disease",
issn = "1398-2273",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Mycobacterium chelonae necrotizing pneumonia after allogeneic hematopoietic stem cell transplant

T2 - Report of clinical response to treatment with tigecycline

AU - Peres, E.

AU - Khaled, Yasser

AU - Krijanovski, O. I.

AU - Mineishi, S.

AU - Levine, J. E.

AU - Kaul, D. R.

AU - Riddell IV, J.

PY - 2009/2/1

Y1 - 2009/2/1

N2 - We present a case of progressive Mycobacterium chelonae ssp. chelonae necrotizing pneumonia after hematopoietic stem cell transplantation (HSCT) in the presence of chronic graft-versus-host disease. The patient failed to respond to standard combination therapy with multiple agents and developed resistance to most drugs over the course of treatment. Tigecycline, a new glycylcycline antimicrobial agent with in vitro activity against M. chelonae, was then used with a clinical response to treatment. To our knowledge, this is the first reported case demonstrating tigecycline to have a degree of clinical effectiveness to treat refractory pulmonary infection with M. chelonae in an HSCT recipient.

AB - We present a case of progressive Mycobacterium chelonae ssp. chelonae necrotizing pneumonia after hematopoietic stem cell transplantation (HSCT) in the presence of chronic graft-versus-host disease. The patient failed to respond to standard combination therapy with multiple agents and developed resistance to most drugs over the course of treatment. Tigecycline, a new glycylcycline antimicrobial agent with in vitro activity against M. chelonae, was then used with a clinical response to treatment. To our knowledge, this is the first reported case demonstrating tigecycline to have a degree of clinical effectiveness to treat refractory pulmonary infection with M. chelonae in an HSCT recipient.

UR - http://www.scopus.com/inward/record.url?scp=58649097733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58649097733&partnerID=8YFLogxK

U2 - 10.1111/j.1399-3062.2008.00351.x

DO - 10.1111/j.1399-3062.2008.00351.x

M3 - Article

VL - 11

SP - 57

EP - 63

JO - Transplant Infectious Disease

JF - Transplant Infectious Disease

SN - 1398-2273

IS - 1

ER -