Mycobacterium kansasii infection diagnosed by pleural fluid cytology

A case report

Akosua B. Domfeh, Laurentia Nodit, Joel Gradowski, Sheldon Bastacky

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Identification of disseminated nontuberculous Mycobacterium infection is a challenge, especially when it occurs in patients without a known cause of immunosuppression. Acid-fast organisms in the pleural fluid are rare and easily missed, especially when they occur in patients without a clinical suspicion of infection. The classical cytologic picture of tuberculous pleural fluid with lymphocytosis and paucity of mesothelial cells is not seen. Case: A 57-year-old man presented with chronic neutrophilia of unknown etiology together with chest pain and bilateral pleural effusions. Pleural fluid cytology revealed organisms seen in the cytoplasm of numerous macrophages and neutrophils, creating a "negative image" on Diff-Quik smears. Acid-fast stains demonstrated intracellular acid-fast bacilli consistent with mycobacteria. Microbiologic studies with DNA probe technology resulted in identification of the mycobacterial organism as Mycobacterium kansasii. Conclusion: Nontuberculous Mycobacterium should be included in the differential diagnosis in patients with inflammatory, exudative pleural effusions.

Original languageEnglish (US)
Pages (from-to)627-630
Number of pages4
JournalActa Cytologica
Volume51
Issue number4
DOIs
StatePublished - Jan 1 2007

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Mycobacterium kansasii
Mycobacterium Infections
Cell Biology
Pleural Effusion
Acids
Nontuberculous Mycobacterium Infections
Nontuberculous Mycobacteria
Lymphocytosis
DNA Probes
Mycobacterium
Chest Pain
Immunosuppression
Bacillus
Cytoplasm
Neutrophils
Differential Diagnosis
Coloring Agents
Macrophages
Technology
Infection

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

Mycobacterium kansasii infection diagnosed by pleural fluid cytology : A case report. / Domfeh, Akosua B.; Nodit, Laurentia; Gradowski, Joel; Bastacky, Sheldon.

In: Acta Cytologica, Vol. 51, No. 4, 01.01.2007, p. 627-630.

Research output: Contribution to journalArticle

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