Myocardial fibrosis in hypertensive heart disease

An overview of potential regulatory mechanisms

Karl Weber, Yao Sun, E. Guarda, L. C. Katwa, A. Ratajska, J. P M Cleutiens, G. Zhou

Research output: Contribution to journalShort survey

54 Citations (Scopus)

Abstract

Myocardial fibrosis in hypertensive heart disease (HHD) can present as a reactive process, involving intramocardial coronary arteries and arterioles with extensions of collagen into the neighbouring interstitial space, and as a replacement for necrotic cardiac myocytes. Fibrosis adversely affects myocardial stiffness and therefore regulatory mechanisms are of considerable interest. Mechanisms responsible for scarring (reparative fibrosis) are based on factors that adversely influence myocyte survival. This topic is not covered in this brief review. Mechanisms responsible for the perivascular/interstitial fibirosis that appear in both the normotensive, non-hypertrophied right and the pressure overload,hypertrophied left ventricle in HHD are addressed herein. They include: (a) angiotensin II (Ang II)-mediated coronary vascular hyperpermeability with subsequent fibrosis; (b) direct hormonal regulation of fibroblast collagen turnover, whereby Ang II, aldosterone and/or endothelins may be involved; (c) autocrine and paracrine signalling between fibroblasts and/or endothelial cells that alters collagen synthesis and degradation and which includes an angiotensin converting enzyme found in fibrosis tissue. Collagen turnover in the myocardium is a dynamic process and fibrous tissue is anything but inert.

Original languageEnglish (US)
Pages (from-to)24-28
Number of pages5
JournalEuropean Heart Journal
Volume16
Issue numberSUPPL. C
StatePublished - 1995
Externally publishedYes

Fingerprint

Heart Diseases
Fibrosis
Collagen
Angiotensin II
Fibroblasts
Autocrine Communication
Paracrine Communication
Endothelins
Arterioles
Peptidyl-Dipeptidase A
Aldosterone
Cardiac Myocytes
Muscle Cells
Heart Ventricles
Cicatrix
Blood Vessels
Coronary Vessels
Myocardium
Endothelial Cells
Pressure

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Weber, K., Sun, Y., Guarda, E., Katwa, L. C., Ratajska, A., Cleutiens, J. P. M., & Zhou, G. (1995). Myocardial fibrosis in hypertensive heart disease: An overview of potential regulatory mechanisms. European Heart Journal, 16(SUPPL. C), 24-28.

Myocardial fibrosis in hypertensive heart disease : An overview of potential regulatory mechanisms. / Weber, Karl; Sun, Yao; Guarda, E.; Katwa, L. C.; Ratajska, A.; Cleutiens, J. P M; Zhou, G.

In: European Heart Journal, Vol. 16, No. SUPPL. C, 1995, p. 24-28.

Research output: Contribution to journalShort survey

Weber, K, Sun, Y, Guarda, E, Katwa, LC, Ratajska, A, Cleutiens, JPM & Zhou, G 1995, 'Myocardial fibrosis in hypertensive heart disease: An overview of potential regulatory mechanisms', European Heart Journal, vol. 16, no. SUPPL. C, pp. 24-28.
Weber, Karl ; Sun, Yao ; Guarda, E. ; Katwa, L. C. ; Ratajska, A. ; Cleutiens, J. P M ; Zhou, G. / Myocardial fibrosis in hypertensive heart disease : An overview of potential regulatory mechanisms. In: European Heart Journal. 1995 ; Vol. 16, No. SUPPL. C. pp. 24-28.
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