Myocardial fibrosis

role of ventricular systolic pressure, arterial hypertension, and circulating hormones.

Karl Weber, C. G. Brilla, J. S. Janicki, H. K. Reddy, S. E. Campbell

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The myocardium contains myocyte and non-myocyte cells. A disproportionate growth of the nonmyocyte cell population can alter myocardial structure and lead to pathologic hypertrophy. Myocardial fibrosis, the result of cardiac fibroblast growth or abnormal accumulation of fibrillar collagen within the interstitial space, can adversely influence myocardial stiffness and ultimately ventricular function. We have examined the relative importance of ventricular systolic and arterial pressures and the effector hormones of the renin-angiotensin--aldosterone system in mediating this reactive fibrous tissue response in the hypertensive left and normotensive right ventricles in various experimental models of arterial hypertension. To date, our findings implicate arterial hypertension, together with an elevation in plasma aldosterone, as being contributory to the fibrosis in renovascular hypertension that creates tissue heterogeneity in either ventricle and impaired diastolic function. The endocrine properties of aldosterone in this nonclassical mineralocorticoid target tissue, the myocardium, requires further investigation.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalBasic Research in Cardiology
Volume86 Suppl 3
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Ventricular Pressure
Fibrosis
Hormones
Blood Pressure
Hypertension
Aldosterone
Myocardium
Fibrillar Collagens
Mineralocorticoids
Renovascular Hypertension
Ventricular Function
Renin-Angiotensin System
Growth
Muscle Cells
Hypertrophy
Heart Ventricles
Arterial Pressure
Theoretical Models
Fibroblasts
Population

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Myocardial fibrosis : role of ventricular systolic pressure, arterial hypertension, and circulating hormones. / Weber, Karl; Brilla, C. G.; Janicki, J. S.; Reddy, H. K.; Campbell, S. E.

In: Basic Research in Cardiology, Vol. 86 Suppl 3, 01.01.1991, p. 25-31.

Research output: Contribution to journalArticle

Weber, Karl ; Brilla, C. G. ; Janicki, J. S. ; Reddy, H. K. ; Campbell, S. E. / Myocardial fibrosis : role of ventricular systolic pressure, arterial hypertension, and circulating hormones. In: Basic Research in Cardiology. 1991 ; Vol. 86 Suppl 3. pp. 25-31.
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