Myofiber degeneration/regeneration is induced in the cachectic Apc Min/+ mouse

Kristeil A. Mehl, J. Mark Davis, Franklin G. Berger, James Carson

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Cachexia is characterized as an inflammatory state induced by the cancer environment, which is accompanied by the loss of muscle and fat mass. Well-investigated mechanisms of cachexia include the suppression of myofiber protein synthesis and the induction of the protein degradation. However, it is not well characterized whether chronic inflammation during cachexia induces myofiber degeneration, which contributes to muscle mass loss and decreased functional capacity. The purpose of this study was to determine whether Apc Min/+ mice, which demonstrate a chronic systemic inflammatory state due to an intestinal tumor burden, undergo cachexia and whether the myofibers exhibit signs of degeneration and/or regeneration. Six-month-old female Apc Min/+ body weight decreased 21% compared with C57BL/6 mice and was not the result of blunted growth. ApcMin/+ gastrocnemius muscle was reduced 45%, and soleus mean fiber cross-sectional area decreased 24% vs. C57BL/6 mice. Soleus muscle morphology demonstrated pathology of myofibers undergoing degeneration and/or regeneration. These data demonstrate that the ApcMin/+ mouse becomes cachectic by 6 mo of age and that skeletal muscle degeneration and regeneration may be related to the muscle loss.

Original languageEnglish (US)
Pages (from-to)2379-2387
Number of pages9
JournalJournal of Applied Physiology
Volume99
Issue number6
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

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Cachexia
Regeneration
Skeletal Muscle
Inbred C57BL Mouse
Muscles
Tumor Burden
Proteolysis
Fats
Body Weight
Pathology
Inflammation
Growth
Neoplasms
Proteins

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Myofiber degeneration/regeneration is induced in the cachectic Apc Min/+ mouse. / Mehl, Kristeil A.; Davis, J. Mark; Berger, Franklin G.; Carson, James.

In: Journal of Applied Physiology, Vol. 99, No. 6, 01.12.2005, p. 2379-2387.

Research output: Contribution to journalArticle

Mehl, Kristeil A. ; Davis, J. Mark ; Berger, Franklin G. ; Carson, James. / Myofiber degeneration/regeneration is induced in the cachectic Apc Min/+ mouse. In: Journal of Applied Physiology. 2005 ; Vol. 99, No. 6. pp. 2379-2387.
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