Myofibroblasts and local angiotensin II in rat cardiac tissue repair

Karl Weber, Yao Sun, Laxmansa C. Katwa

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Tissue repair is a fundamental property of vascularized tissue. At sites of injury, phenotypically transformed fibroblast-like cells are responsible for fibrous tissue formation, expressed principally as type I and III fibrillar collagens. These cells are termed myofibroblasts because they contain α-smooth muscle actin microfilaments and are contractile. In vivo studies of injured rat cardiac tissues and in vitro cell culture studies have shown that such fibroblast-like cells contain requisite components for angiotensin peptide generation and angiotensin II receptors. Such locally generated angiotensin II acts in an autocrine/paracrine manner to regulate collagen turnover and thereby tissue homeostasis in injured tissue.

Original languageEnglish (US)
Pages (from-to)31-42
Number of pages12
JournalInternational Journal of Biochemistry and Cell Biology
Volume29
Issue number1
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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Myofibroblasts
Angiotensin II
Rats
Repair
Tissue
Fibroblasts
Tissue homeostasis
Fibrillar Collagens
Angiotensin Receptors
Angiotensins
Cell culture
Muscle
Actins
Actin Cytoskeleton
Collagen
Smooth Muscle
Homeostasis
Cell Culture Techniques
Peptides
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology

Cite this

Myofibroblasts and local angiotensin II in rat cardiac tissue repair. / Weber, Karl; Sun, Yao; Katwa, Laxmansa C.

In: International Journal of Biochemistry and Cell Biology, Vol. 29, No. 1, 01.01.1997, p. 31-42.

Research output: Contribution to journalReview article

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