Myoglobin as an early indicator of acute myocardial infarction

W. Brian Gibler, Clinton D. Gibler, Eugene Weinshenker, Charles Abbottsmith, Jerris R. Hedges, William G. Barsan, Matthew Sperling, I. Wen Chen, Steven Embry, Dean Kereiakes

    Research output: Contribution to journalArticle

    85 Citations (Scopus)

    Abstract

    The ECG and the determination of serum enzymes creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) may be falsely normal early in acute myocardial infarction. Myoglobin, an oxygen-carrying protein found in cardiac muscle and striated skeletal muscle, presents an attractive alternative to CPK and LDH in the emergency department setting for identification of acute myocardial infarction. Myoglobin levels may be elevated in the serum within one hour after myocardial cell death with peak levels reached within four to six hours. We report a study of 59 patients presenting to a community hospital with chest pain and subsequent hospitalization. Twenty-one had an acute myocardial infarction. Presenting (0 hour) myoglobin determination was positive in 13 of 21 individuals, while CPK-MB was positive in only three. Serum myoglobin elevation at three hours identified all 21 patients with myocardial infarction with the CPK-MB determination positive in 19. Serum myoglobin elevation may permit early identification of myocardial infarction, with subsequent verification using CPK-MB determination, allowing appropriate intensive care admission for careful monitoring of these patients.

    Original languageEnglish (US)
    Pages (from-to)851-856
    Number of pages6
    JournalAnnals of Emergency Medicine
    Volume16
    Issue number8
    DOIs
    StatePublished - Jan 1 1987

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    Myoglobin
    Creatine Kinase
    Myocardial Infarction
    Serum
    L-Lactate Dehydrogenase
    Striated Muscle
    Community Hospital
    Physiologic Monitoring
    Critical Care
    Chest Pain
    Hospital Emergency Service
    Myocardium
    Electrocardiography
    Skeletal Muscle
    Hospitalization
    Cell Death
    Oxygen
    Enzymes
    Proteins

    All Science Journal Classification (ASJC) codes

    • Emergency Medicine

    Cite this

    Brian Gibler, W., Gibler, C. D., Weinshenker, E., Abbottsmith, C., Hedges, J. R., Barsan, W. G., ... Kereiakes, D. (1987). Myoglobin as an early indicator of acute myocardial infarction. Annals of Emergency Medicine, 16(8), 851-856. https://doi.org/10.1016/S0196-0644(87)80521-8

    Myoglobin as an early indicator of acute myocardial infarction. / Brian Gibler, W.; Gibler, Clinton D.; Weinshenker, Eugene; Abbottsmith, Charles; Hedges, Jerris R.; Barsan, William G.; Sperling, Matthew; Chen, I. Wen; Embry, Steven; Kereiakes, Dean.

    In: Annals of Emergency Medicine, Vol. 16, No. 8, 01.01.1987, p. 851-856.

    Research output: Contribution to journalArticle

    Brian Gibler, W, Gibler, CD, Weinshenker, E, Abbottsmith, C, Hedges, JR, Barsan, WG, Sperling, M, Chen, IW, Embry, S & Kereiakes, D 1987, 'Myoglobin as an early indicator of acute myocardial infarction', Annals of Emergency Medicine, vol. 16, no. 8, pp. 851-856. https://doi.org/10.1016/S0196-0644(87)80521-8
    Brian Gibler W, Gibler CD, Weinshenker E, Abbottsmith C, Hedges JR, Barsan WG et al. Myoglobin as an early indicator of acute myocardial infarction. Annals of Emergency Medicine. 1987 Jan 1;16(8):851-856. https://doi.org/10.1016/S0196-0644(87)80521-8
    Brian Gibler, W. ; Gibler, Clinton D. ; Weinshenker, Eugene ; Abbottsmith, Charles ; Hedges, Jerris R. ; Barsan, William G. ; Sperling, Matthew ; Chen, I. Wen ; Embry, Steven ; Kereiakes, Dean. / Myoglobin as an early indicator of acute myocardial infarction. In: Annals of Emergency Medicine. 1987 ; Vol. 16, No. 8. pp. 851-856.
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