N-cadherin switching occurs in high Gleason grade prostate cancer

Meena Jaggi, Tanya Nazemi, Neil A. Abrahams, John J. Baker, Anton Galich, Lynette M. Smith, K. C. Balaji

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

BACKGROUND. The inappropriate expression of non-epithelial N-(neural) cadherin by epithelial cells, called cadherin switching, has been suggested to play a role in prostate cancer (PC) progression. We explored the role of N-cadherin as a biomarker in PC by correlating the expression with clinical parameters. METHODS. Two pathologists blinded to patients' history independently reviewed and scored the intensity and extent of staining of N-cadherin expression in 44 randomly selected radical prostatectomy specimens. The expression was correlated with total Gleason grade, individual Gleason patterns, tumor stage, and preoperative serum prostate specific antigen (PSA) levels and P-values <0.05 were considered statistically significant. RESULTS. Of the 44 PC specimens, 14 (32%), 23 (52%), 7 (16%) consisted of Gleason grade 5-6, 7, and 8-10, respectively and 20/44 (45%) demonstrated N-cadherin expression. N-cadherin was expressed in 1/14 (7%) of Gleason 5-6 compared to 15/23 (65%) of Gleason grade 7, and 4/7 (57%) of Gleason grade 8-10, demonstrating a significant correlation between N-cadherin switching and higher Gleason grade (P = 0.001). While only about a third of primary or secondary Gleason pattern 3 demonstrated N-cadherin expression, a majority of Gleason patterns of ≥4 expressed N-cadherin (P > 0.05), further suggesting that N-cadherin switching occurs with higher Gleason pattern. However, N-cadherin expression did not significantly correlate with preoperative serum PSA levels or tumor stage in our study cohort. CONCLUSIONS. We have demonstrated for the first time that N-cadherin switching occurs in higher grade PC and correlates significantly with increasing Gleason patterns. N-cadherin may be as a useful biomarker of aggressive PC.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalProstate
Volume66
Issue number2
DOIs
StatePublished - Feb 1 2006
Externally publishedYes

Fingerprint

Cadherins
Prostatic Neoplasms
Prostate-Specific Antigen
Biomarkers
Prostatectomy
Serum
Neoplasms
Cohort Studies
History
Epithelial Cells
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Jaggi, M., Nazemi, T., Abrahams, N. A., Baker, J. J., Galich, A., Smith, L. M., & Balaji, K. C. (2006). N-cadherin switching occurs in high Gleason grade prostate cancer. Prostate, 66(2), 193-199. https://doi.org/10.1002/pros.20334

N-cadherin switching occurs in high Gleason grade prostate cancer. / Jaggi, Meena; Nazemi, Tanya; Abrahams, Neil A.; Baker, John J.; Galich, Anton; Smith, Lynette M.; Balaji, K. C.

In: Prostate, Vol. 66, No. 2, 01.02.2006, p. 193-199.

Research output: Contribution to journalArticle

Jaggi, M, Nazemi, T, Abrahams, NA, Baker, JJ, Galich, A, Smith, LM & Balaji, KC 2006, 'N-cadherin switching occurs in high Gleason grade prostate cancer', Prostate, vol. 66, no. 2, pp. 193-199. https://doi.org/10.1002/pros.20334
Jaggi M, Nazemi T, Abrahams NA, Baker JJ, Galich A, Smith LM et al. N-cadherin switching occurs in high Gleason grade prostate cancer. Prostate. 2006 Feb 1;66(2):193-199. https://doi.org/10.1002/pros.20334
Jaggi, Meena ; Nazemi, Tanya ; Abrahams, Neil A. ; Baker, John J. ; Galich, Anton ; Smith, Lynette M. ; Balaji, K. C. / N-cadherin switching occurs in high Gleason grade prostate cancer. In: Prostate. 2006 ; Vol. 66, No. 2. pp. 193-199.
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abstract = "BACKGROUND. The inappropriate expression of non-epithelial N-(neural) cadherin by epithelial cells, called cadherin switching, has been suggested to play a role in prostate cancer (PC) progression. We explored the role of N-cadherin as a biomarker in PC by correlating the expression with clinical parameters. METHODS. Two pathologists blinded to patients' history independently reviewed and scored the intensity and extent of staining of N-cadherin expression in 44 randomly selected radical prostatectomy specimens. The expression was correlated with total Gleason grade, individual Gleason patterns, tumor stage, and preoperative serum prostate specific antigen (PSA) levels and P-values <0.05 were considered statistically significant. RESULTS. Of the 44 PC specimens, 14 (32{\%}), 23 (52{\%}), 7 (16{\%}) consisted of Gleason grade 5-6, 7, and 8-10, respectively and 20/44 (45{\%}) demonstrated N-cadherin expression. N-cadherin was expressed in 1/14 (7{\%}) of Gleason 5-6 compared to 15/23 (65{\%}) of Gleason grade 7, and 4/7 (57{\%}) of Gleason grade 8-10, demonstrating a significant correlation between N-cadherin switching and higher Gleason grade (P = 0.001). While only about a third of primary or secondary Gleason pattern 3 demonstrated N-cadherin expression, a majority of Gleason patterns of ≥4 expressed N-cadherin (P > 0.05), further suggesting that N-cadherin switching occurs with higher Gleason pattern. However, N-cadherin expression did not significantly correlate with preoperative serum PSA levels or tumor stage in our study cohort. CONCLUSIONS. We have demonstrated for the first time that N-cadherin switching occurs in higher grade PC and correlates significantly with increasing Gleason patterns. N-cadherin may be as a useful biomarker of aggressive PC.",
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AU - Jaggi, Meena

AU - Nazemi, Tanya

AU - Abrahams, Neil A.

AU - Baker, John J.

AU - Galich, Anton

AU - Smith, Lynette M.

AU - Balaji, K. C.

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N2 - BACKGROUND. The inappropriate expression of non-epithelial N-(neural) cadherin by epithelial cells, called cadherin switching, has been suggested to play a role in prostate cancer (PC) progression. We explored the role of N-cadherin as a biomarker in PC by correlating the expression with clinical parameters. METHODS. Two pathologists blinded to patients' history independently reviewed and scored the intensity and extent of staining of N-cadherin expression in 44 randomly selected radical prostatectomy specimens. The expression was correlated with total Gleason grade, individual Gleason patterns, tumor stage, and preoperative serum prostate specific antigen (PSA) levels and P-values <0.05 were considered statistically significant. RESULTS. Of the 44 PC specimens, 14 (32%), 23 (52%), 7 (16%) consisted of Gleason grade 5-6, 7, and 8-10, respectively and 20/44 (45%) demonstrated N-cadherin expression. N-cadherin was expressed in 1/14 (7%) of Gleason 5-6 compared to 15/23 (65%) of Gleason grade 7, and 4/7 (57%) of Gleason grade 8-10, demonstrating a significant correlation between N-cadherin switching and higher Gleason grade (P = 0.001). While only about a third of primary or secondary Gleason pattern 3 demonstrated N-cadherin expression, a majority of Gleason patterns of ≥4 expressed N-cadherin (P > 0.05), further suggesting that N-cadherin switching occurs with higher Gleason pattern. However, N-cadherin expression did not significantly correlate with preoperative serum PSA levels or tumor stage in our study cohort. CONCLUSIONS. We have demonstrated for the first time that N-cadherin switching occurs in higher grade PC and correlates significantly with increasing Gleason patterns. N-cadherin may be as a useful biomarker of aggressive PC.

AB - BACKGROUND. The inappropriate expression of non-epithelial N-(neural) cadherin by epithelial cells, called cadherin switching, has been suggested to play a role in prostate cancer (PC) progression. We explored the role of N-cadherin as a biomarker in PC by correlating the expression with clinical parameters. METHODS. Two pathologists blinded to patients' history independently reviewed and scored the intensity and extent of staining of N-cadherin expression in 44 randomly selected radical prostatectomy specimens. The expression was correlated with total Gleason grade, individual Gleason patterns, tumor stage, and preoperative serum prostate specific antigen (PSA) levels and P-values <0.05 were considered statistically significant. RESULTS. Of the 44 PC specimens, 14 (32%), 23 (52%), 7 (16%) consisted of Gleason grade 5-6, 7, and 8-10, respectively and 20/44 (45%) demonstrated N-cadherin expression. N-cadherin was expressed in 1/14 (7%) of Gleason 5-6 compared to 15/23 (65%) of Gleason grade 7, and 4/7 (57%) of Gleason grade 8-10, demonstrating a significant correlation between N-cadherin switching and higher Gleason grade (P = 0.001). While only about a third of primary or secondary Gleason pattern 3 demonstrated N-cadherin expression, a majority of Gleason patterns of ≥4 expressed N-cadherin (P > 0.05), further suggesting that N-cadherin switching occurs with higher Gleason pattern. However, N-cadherin expression did not significantly correlate with preoperative serum PSA levels or tumor stage in our study cohort. CONCLUSIONS. We have demonstrated for the first time that N-cadherin switching occurs in higher grade PC and correlates significantly with increasing Gleason patterns. N-cadherin may be as a useful biomarker of aggressive PC.

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DO - 10.1002/pros.20334

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