Nandrolone decanoate modulates cell cycle regulation in functionally overloaded rat soleus muscle

Joseph M. McClung, Kristen A. Mehl, Raymond W. Thompson, Larry L. Lowe, James Carson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Functionally overloading rat soleus muscle by synergist ablation induces a rapid increase in mass. Muscle remodeling during the first week of overload is critical for the overload-induced growth. Anabolic steroid modulation of this overload-induced remodeling response is not well understood. The purpose of this study was to determine whether pretreatment with nandrolone decanoate, a clinically administered anabolic steroid, alters muscle morphology and gene expression related to muscle growth during the initiation of functional overload in the rat soleus muscle. Adult (5 mo) male Fisher 344 X Brown Norway rats were randomly assigned to control (Sham), 3-day functional overload (OV), nandrolone decanoate administration (ND), or 3-day functional overload with nandrolone decanoate administration (OV+ND) treatment groups. Morphologically, OV increased the percentage of small (361%) and large (150%) fibers and expanded the ECM 50%. ND administration decreased the 3-day OV induction of small fibers 51% and nuclei associated with the ECM 20%. ND administration also attenuated the induction of cell cycle regulator p21 (64%) and myogenin (37%) mRNAs after 3 days of overload. These data demonstrate that nandrolone decanoate pretreatment can alter morphological and cell cycle regulator expression related to muscle growth at the onset of functional overload.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume288
Issue number6 57-6
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

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Cell Cycle
Skeletal Muscle
Testosterone Congeners
Muscles
Growth
Cyclin-Dependent Kinase Inhibitor p21
Myogenin
nandrolone decanoate
Gene Expression
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Nandrolone decanoate modulates cell cycle regulation in functionally overloaded rat soleus muscle. / McClung, Joseph M.; Mehl, Kristen A.; Thompson, Raymond W.; Lowe, Larry L.; Carson, James.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 288, No. 6 57-6, 01.06.2005.

Research output: Contribution to journalArticle

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