Nanomaterial exposure induced neutrophil extracellular traps: A new target in inflammation and innate immunity

Hang Yang, Tony Marion, Yi Liu, Lingshu Zhang, Xue Cao, Huifang Hu, Yi Zhao, Martin Herrmann

Research output: Contribution to journalReview article

Abstract

Nanotechnology has become a novel subject with impact in many research and technology areas. Nanoparticles (NPs), as a key component in nanotechnology, are widely used in many areas such as optical, magnetic, electrical, and mechanical engineering. The biomedical and pharmaceutical industries have embraced NPs as a viable drug delivery modality. As such, the potential for NP-induced cytotoxicity has emerged as a major concern for NP drug delivery systems. Thus, it is important to understand how NPs affect the innate immune system. As the most abundant myeloid cell type in innate immune responses, neutrophils are critical for concerns about potentially toxic side effects of NPs. When activated by innate immune stimuli, neutrophils may initiate NETosis to release neutrophil extracellular traps (NETs). Herein, we have reviewed the relationship between NPs and the induction of NETosis and release of NETs.

Original languageEnglish (US)
Article number3560180
JournalJournal of immunology research
Volume2019
DOIs
StatePublished - Jan 1 2019

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Nanostructures
Innate Immunity
Nanoparticles
Inflammation
Nanotechnology
Neutrophils
Poisons
Drug Industry
Myeloid Cells
Drug Delivery Systems
Extracellular Traps
Immune System
Technology
Research
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Nanomaterial exposure induced neutrophil extracellular traps : A new target in inflammation and innate immunity. / Yang, Hang; Marion, Tony; Liu, Yi; Zhang, Lingshu; Cao, Xue; Hu, Huifang; Zhao, Yi; Herrmann, Martin.

In: Journal of immunology research, Vol. 2019, 3560180, 01.01.2019.

Research output: Contribution to journalReview article

Yang, Hang ; Marion, Tony ; Liu, Yi ; Zhang, Lingshu ; Cao, Xue ; Hu, Huifang ; Zhao, Yi ; Herrmann, Martin. / Nanomaterial exposure induced neutrophil extracellular traps : A new target in inflammation and innate immunity. In: Journal of immunology research. 2019 ; Vol. 2019.
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