Narcotic-induced histamine release

A comparison of morphine, oxymorphone, and fentanyl infusions

Mark A. Warner, Michael Hosking, John R. Gray, Diane L. Squillace, John W. Yunginger, Thomas A. Orszulak

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This study, using an improved histamine assay, repeated previous studies that demonstrated large doses of morphine for induction of anesthesia in patients undergoing coronary artery bypass grafting were associated with histamine release. Thirty randomized patients received infusions of either morphine, 1 mg/kg, oxymorphone, 0.2 mg/kg, or fentanyl, 50 μg/kg, over a 10-minute period for induction of anesthesia prior to surgery. There were no significant changes in plasma histamine levels in individual patients or among drug groups. The discrepancy between the present histamine results and those previously reported using similar protocols is due, in part, to variations in plasma histamine measurements that can occur using the less reproducible, older assays for histamine. During routine inductions, large doses of morphine, oxymorphone, or fentanyl administered by infusion do not appear to stimulate release of clinically significant plasma levels of histamine.

Original languageEnglish (US)
Pages (from-to)481-484
Number of pages4
JournalJournal of Cardiothoracic and Vascular Anesthesia
Volume5
Issue number5
DOIs
StatePublished - Jan 1 1991

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Oxymorphone
Histamine Release
Narcotics
Fentanyl
Morphine
Histamine
Anesthesia
Coronary Artery Bypass

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Narcotic-induced histamine release : A comparison of morphine, oxymorphone, and fentanyl infusions. / Warner, Mark A.; Hosking, Michael; Gray, John R.; Squillace, Diane L.; Yunginger, John W.; Orszulak, Thomas A.

In: Journal of Cardiothoracic and Vascular Anesthesia, Vol. 5, No. 5, 01.01.1991, p. 481-484.

Research output: Contribution to journalArticle

Warner, Mark A. ; Hosking, Michael ; Gray, John R. ; Squillace, Diane L. ; Yunginger, John W. ; Orszulak, Thomas A. / Narcotic-induced histamine release : A comparison of morphine, oxymorphone, and fentanyl infusions. In: Journal of Cardiothoracic and Vascular Anesthesia. 1991 ; Vol. 5, No. 5. pp. 481-484.
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