Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product

Margaret L. Gulley, John M. Nicholls, Barbara G. Schneider, Mahul Amin, Jae Y. Ro, Joseph Geradts

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The p16/MTS1 gene is altered by deletion, mutation, or hypermethylation in a wide variety of human cancers. As a result of deficient p16 protein, these cancers lack a critical mechanism for halting G1/S cell cycle progression. In the current study, 59 cases of nasopharyngeal carcinoma were evaluated for expression of the p16 rumor suppressor protein by immunohistochemical analysis of paraffin-embedded tissue. There was no detectable p16 in 38/59 cases (64%), which implies a very high rate of p16 inactivation in this type of cancer. On the other hand, the retinoblastoma gene product, which also regulates the G1 to S phase transition of the cell cycle, was consistently expressed in nasopharyngeal carcinomas by immunohistochemical analysis. These results implicate p16 inactivation but not Rb alteration in the stepwise progression of nasopharyngeal carcinogenesis.

Original languageEnglish (US)
Pages (from-to)865-869
Number of pages5
JournalAmerican Journal of Pathology
Volume152
Issue number4
StatePublished - Apr 1 1998
Externally publishedYes

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Cyclin-Dependent Kinase Inhibitor p16
Retinoblastoma Genes
Tumor Suppressor Proteins
p16 Genes
Cell Cycle
Neoplasms
Sequence Deletion
Phase Transition
S Phase
Paraffin
Carcinogenesis
Proteins
Nasopharyngeal carcinoma

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product. / Gulley, Margaret L.; Nicholls, John M.; Schneider, Barbara G.; Amin, Mahul; Ro, Jae Y.; Geradts, Joseph.

In: American Journal of Pathology, Vol. 152, No. 4, 01.04.1998, p. 865-869.

Research output: Contribution to journalArticle

Gulley, Margaret L. ; Nicholls, John M. ; Schneider, Barbara G. ; Amin, Mahul ; Ro, Jae Y. ; Geradts, Joseph. / Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product. In: American Journal of Pathology. 1998 ; Vol. 152, No. 4. pp. 865-869.
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