Natural infection of Neotropical bats with hantavirus in Brazil

Gilberto Sabino-Santos, Felipe Gonçalves Motta Maia, Ronaldo Bragança Martins, Talita Bianca Gagliardi, William Marciel De Souza, Renata Lara Muylaert, Luciano Kleber De Souza Luna, Danilo Machado Melo, Ricardo De Souza Cardoso, Natalia Da Silva Barbosa, Marjorie Cornejo Pontelli, Priscila Rosse Mamani-Zapana, Thallyta Maria Vieira, Norma Maria Melo, Colleen Jonsson, Douglas Goodin, Jorge Salazar-Bravo, Luis Lamberti Pinto Dasilva, Eurico Arruda, Luiz Tadeu Moraes Figueiredo

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Abstract

Bats (Order: Chiroptera) harbor a high diversity of emerging pathogens presumably because their ability to fly and social behavior favor the maintenance, evolution, and dissemination of these pathogens. Until 2012, there was only one report of the presence of Hantavirus in bats. Historically, it was thought that these viruses were harbored primarily by rodent and insectivore small mammals. Recently, new species of hantaviruses have been identified in bats from Africa and Asia continents expanding the potential reservoirs and range of these viruses. To assess the potential of Neotropical bats as hosts for hantaviruses and its transmission dynamics in nature, we tested 53 bats for active hantaviral infection from specimens collected in Southeastern Brazil. Part of the hantaviral S segment was amplified from the frugivorous Carollia perspicillata and the common vampire bat Desmodus rotundus. DNA sequencing showed high similarity with the genome of Araraquara orthohantavirus (ARQV), which belongs to one of the more lethal hantavirus clades (Andes orthohantavirus). ARQV-like infection was detected in the blood, urine, and organs of D. rotundus. Therefore, we describe a systemic infection in Neotropical bats by a human pathogenic Hantavirus. We also propose here a schematic transmission dynamics of hantavirus in the study region. Our results give insights to new, under-appreciated questions that need to be addressed in future studies to clarify hantavirus transmission in nature and avoid hantavirus outbreaks.

Original languageEnglish (US)
Article number9018
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Hantavirus
Chiroptera
Brazil
infection
Desmodus
viruses
insectivores
pathogens
small mammals
social behavior
lethal genes
rodents
urine
sequence analysis
genome
new species
blood

All Science Journal Classification (ASJC) codes

  • General

Cite this

Sabino-Santos, G., Maia, F. G. M., Martins, R. B., Gagliardi, T. B., De Souza, W. M., Muylaert, R. L., ... Figueiredo, L. T. M. (2018). Natural infection of Neotropical bats with hantavirus in Brazil. Scientific Reports, 8(1), [9018]. https://doi.org/10.1038/s41598-018-27442-w

Natural infection of Neotropical bats with hantavirus in Brazil. / Sabino-Santos, Gilberto; Maia, Felipe Gonçalves Motta; Martins, Ronaldo Bragança; Gagliardi, Talita Bianca; De Souza, William Marciel; Muylaert, Renata Lara; Luna, Luciano Kleber De Souza; Melo, Danilo Machado; De Souza Cardoso, Ricardo; Da Silva Barbosa, Natalia; Pontelli, Marjorie Cornejo; Mamani-Zapana, Priscila Rosse; Vieira, Thallyta Maria; Melo, Norma Maria; Jonsson, Colleen; Goodin, Douglas; Salazar-Bravo, Jorge; Dasilva, Luis Lamberti Pinto; Arruda, Eurico; Figueiredo, Luiz Tadeu Moraes.

In: Scientific Reports, Vol. 8, No. 1, 9018, 01.12.2018.

Research output: Contribution to journalArticle

Sabino-Santos, G, Maia, FGM, Martins, RB, Gagliardi, TB, De Souza, WM, Muylaert, RL, Luna, LKDS, Melo, DM, De Souza Cardoso, R, Da Silva Barbosa, N, Pontelli, MC, Mamani-Zapana, PR, Vieira, TM, Melo, NM, Jonsson, C, Goodin, D, Salazar-Bravo, J, Dasilva, LLP, Arruda, E & Figueiredo, LTM 2018, 'Natural infection of Neotropical bats with hantavirus in Brazil', Scientific Reports, vol. 8, no. 1, 9018. https://doi.org/10.1038/s41598-018-27442-w
Sabino-Santos G, Maia FGM, Martins RB, Gagliardi TB, De Souza WM, Muylaert RL et al. Natural infection of Neotropical bats with hantavirus in Brazil. Scientific Reports. 2018 Dec 1;8(1). 9018. https://doi.org/10.1038/s41598-018-27442-w
Sabino-Santos, Gilberto ; Maia, Felipe Gonçalves Motta ; Martins, Ronaldo Bragança ; Gagliardi, Talita Bianca ; De Souza, William Marciel ; Muylaert, Renata Lara ; Luna, Luciano Kleber De Souza ; Melo, Danilo Machado ; De Souza Cardoso, Ricardo ; Da Silva Barbosa, Natalia ; Pontelli, Marjorie Cornejo ; Mamani-Zapana, Priscila Rosse ; Vieira, Thallyta Maria ; Melo, Norma Maria ; Jonsson, Colleen ; Goodin, Douglas ; Salazar-Bravo, Jorge ; Dasilva, Luis Lamberti Pinto ; Arruda, Eurico ; Figueiredo, Luiz Tadeu Moraes. / Natural infection of Neotropical bats with hantavirus in Brazil. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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AU - Maia, Felipe Gonçalves Motta

AU - Martins, Ronaldo Bragança

AU - Gagliardi, Talita Bianca

AU - De Souza, William Marciel

AU - Muylaert, Renata Lara

AU - Luna, Luciano Kleber De Souza

AU - Melo, Danilo Machado

AU - De Souza Cardoso, Ricardo

AU - Da Silva Barbosa, Natalia

AU - Pontelli, Marjorie Cornejo

AU - Mamani-Zapana, Priscila Rosse

AU - Vieira, Thallyta Maria

AU - Melo, Norma Maria

AU - Jonsson, Colleen

AU - Goodin, Douglas

AU - Salazar-Bravo, Jorge

AU - Dasilva, Luis Lamberti Pinto

AU - Arruda, Eurico

AU - Figueiredo, Luiz Tadeu Moraes

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