Prirodnye ingibitory proteinaz kaka osnova dlia sozdaniia novykh lekarstvennykh sredstv.

Translated title of the contribution: Natural proteinase inhibitors as a basis for creating new drugs

N. I. Larionova, N. G. Balabushevich, I. P. Gladysheva, N. A. Moroz, N. F. Kazanskaia, O. V. Polekhina, I. A. Donetskiǐ

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Isolation of the proteinases inhibitors, available for medicinal purposes, was described, where the inhibitor of the Kunitz type was obtained from bovine pancreas and the inhibitor of the Bowman-Birk type from soybeans. Screening of the immobilization procedures was carried out, which enabled the authors to produce the polymeric conjugates of the proteinase inhibitors exhibiting the maximal rate of activity against pancreatic proteinases and granulocyte elastases. Pharmacokinetics of the proteinase inhibitors obtained was studied. High molecular derivatives of the inhibitors from the bovine pancreas circulated in rat blood in larger quantities and longer, their total clearance was 5 times than native inhibitor preparations. The preparations containing these inhibitors from bovine pancreas exhibited a high therapeutic efficiency in treatment of rats with hemorrhagic pancreatitis and acute liver failure in rabbits.

Original languageRussian
Pages (from-to)25-31
Number of pages7
JournalVoprosy Meditsinskoj Khimii
Volume40
Issue number3
StatePublished - May 1994
Externally publishedYes

Fingerprint

Peptide Hydrolases
Pancreas
Pharmaceutical Preparations
Rats
Leukocyte Elastase
Pharmacokinetics
Acute Liver Failure
Pancreatic Elastase
Soybeans
Immobilization
Pancreatitis
Liver
Screening
Blood
Rabbits
Derivatives
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biotechnology
  • Clinical Biochemistry
  • Molecular Biology
  • Pharmacology

Cite this

Larionova, N. I., Balabushevich, N. G., Gladysheva, I. P., Moroz, N. A., Kazanskaia, N. F., Polekhina, O. V., & Donetskiǐ, I. A. (1994). Prirodnye ingibitory proteinaz kaka osnova dlia sozdaniia novykh lekarstvennykh sredstv. Voprosy Meditsinskoj Khimii, 40(3), 25-31.

Prirodnye ingibitory proteinaz kaka osnova dlia sozdaniia novykh lekarstvennykh sredstv. / Larionova, N. I.; Balabushevich, N. G.; Gladysheva, I. P.; Moroz, N. A.; Kazanskaia, N. F.; Polekhina, O. V.; Donetskiǐ, I. A.

In: Voprosy Meditsinskoj Khimii, Vol. 40, No. 3, 05.1994, p. 25-31.

Research output: Contribution to journalArticle

Larionova, NI, Balabushevich, NG, Gladysheva, IP, Moroz, NA, Kazanskaia, NF, Polekhina, OV & Donetskiǐ, IA 1994, 'Prirodnye ingibitory proteinaz kaka osnova dlia sozdaniia novykh lekarstvennykh sredstv.', Voprosy Meditsinskoj Khimii, vol. 40, no. 3, pp. 25-31.
Larionova NI, Balabushevich NG, Gladysheva IP, Moroz NA, Kazanskaia NF, Polekhina OV et al. Prirodnye ingibitory proteinaz kaka osnova dlia sozdaniia novykh lekarstvennykh sredstv. Voprosy Meditsinskoj Khimii. 1994 May;40(3):25-31.
Larionova, N. I. ; Balabushevich, N. G. ; Gladysheva, I. P. ; Moroz, N. A. ; Kazanskaia, N. F. ; Polekhina, O. V. ; Donetskiǐ, I. A. / Prirodnye ingibitory proteinaz kaka osnova dlia sozdaniia novykh lekarstvennykh sredstv. In: Voprosy Meditsinskoj Khimii. 1994 ; Vol. 40, No. 3. pp. 25-31.
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