Nefazodone

An update

Steven Laizure, Monica Cyr

Research output: Contribution to journalReview article

Abstract

Nefazodone is an antidepressant with some novel characteristics in regard to its putative mechanism of action. Although the clinical significance of these properties is not clear, nefazodone is unique in that it is associated with minimal effects on sleep architecture and sexual functioning. Use of nefazodone to treat anxiety disorders appears to have promise, although placebo-controlled studies are still needed. Nefazodone is a potent inhibitor of CYP3A4, and thus numerous potential drug interactions must be carefully considered in order to avoid potential therapeutic misadventures. Recent reports indicate that nefazodone can cause severe hepatic toxicity. Evaluation of hepatic function before, and periodically after, therapy with nefazodone is initiated would be prudent. Nefazodone may be an appropriate antidepressant when potential anxiolytic activity would be beneficial and there is a need to avoid adverse effects on sexual functioning or sleep architecture.

Original languageEnglish (US)
Pages (from-to)267-273
Number of pages7
JournalInternational Journal of Psychiatry in Clinical Practice
Volume4
Issue number4
DOIs
StatePublished - Dec 1 2000

Fingerprint

Antidepressive Agents
Sleep
Liver
Anti-Anxiety Agents
nefazodone
Anxiety Disorders
Drug Interactions
Placebos
Therapeutics
Cytochrome P-450 CYP3A Inhibitors

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

Nefazodone : An update. / Laizure, Steven; Cyr, Monica.

In: International Journal of Psychiatry in Clinical Practice, Vol. 4, No. 4, 01.12.2000, p. 267-273.

Research output: Contribution to journalReview article

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