Negative BOLD response and serotonin concentration within rostral subgenual portion of the anterior cingulate cortex for the long-allele carriers during perceptual processing of emotional tasks

Shamil M. Hadi, Mohammad Reza Siadat, Abbas Babajani-Feremi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We investigated the effect of synaptic serotonin concentration on hemodynamic responses. The stimuli paradigm involved the presentation of fearful and threatening facial expressions to a set of 24 subjects who were either5HTTLPR long-or short-allele carriers (12 of each type in each group). The BOLD signals of the rACC from subjects of each group were averaged to increase the signal-to-noise ratio. We used a Bayesian approach to estimate the parameters of the underlying hemodynamic model. Our results, during this perceptual processing of emotional task, showed a negative BOLD signal in the rACC in the subjects with long-alleles. In contrast, the subjects with short-alleles showed positive BOLD signals in the rACC. These results suggest that high synaptic serotonin concentration in the rACC inhibits neuronal activity in a fashion similar to GABA, and a consequent negative BOLD signal ensues.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2012
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
DOIs
StatePublished - May 14 2012
EventMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States
Duration: Feb 5 2012Feb 7 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8317
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego, CA
Period2/5/122/7/12

Fingerprint

serotonin
cortexes
Gyrus Cinguli
Hemodynamics
Serotonin
Alleles
Processing
gamma-Aminobutyric Acid
Signal to noise ratio
Facial Expression
Bayes Theorem
hemodynamic responses
Signal-To-Noise Ratio
hemodynamics
stimuli
signal to noise ratios
estimates

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Hadi, S. M., Siadat, M. R., & Babajani-Feremi, A. (2012). Negative BOLD response and serotonin concentration within rostral subgenual portion of the anterior cingulate cortex for the long-allele carriers during perceptual processing of emotional tasks. In Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging [83170A] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8317). https://doi.org/10.1117/12.905188

Negative BOLD response and serotonin concentration within rostral subgenual portion of the anterior cingulate cortex for the long-allele carriers during perceptual processing of emotional tasks. / Hadi, Shamil M.; Siadat, Mohammad Reza; Babajani-Feremi, Abbas.

Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging. 2012. 83170A (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8317).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hadi, SM, Siadat, MR & Babajani-Feremi, A 2012, Negative BOLD response and serotonin concentration within rostral subgenual portion of the anterior cingulate cortex for the long-allele carriers during perceptual processing of emotional tasks. in Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging., 83170A, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, CA, United States, 2/5/12. https://doi.org/10.1117/12.905188
Hadi SM, Siadat MR, Babajani-Feremi A. Negative BOLD response and serotonin concentration within rostral subgenual portion of the anterior cingulate cortex for the long-allele carriers during perceptual processing of emotional tasks. In Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging. 2012. 83170A. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.905188
Hadi, Shamil M. ; Siadat, Mohammad Reza ; Babajani-Feremi, Abbas. / Negative BOLD response and serotonin concentration within rostral subgenual portion of the anterior cingulate cortex for the long-allele carriers during perceptual processing of emotional tasks. Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging. 2012. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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