Neonatal germ cell tumors

John A. Sandoval, Regan Williams

Research output: Contribution to journalReview article

Abstract

Excluding hemangiomas, germ cell tumors (GCTs) are the most common neoplasm in neo- nates, comprising a wide range of benign and malignant tumors with unique histological diversity. Although these tumors are relatively rare, antenatal ultrasonography has increased their detection be- fore birth. Extragonadal GCTs (EGCTs) are the most common GCTs in neonates, with sacrococcygeal teratomas (SCTs) being the most prevalent EGCTs. SCTs are characterized as protruding masses arising from the sacrococcygeal region with or without variable extension into the presacral space. Patients with SCTs typically have an excellent prognosis, though this is dependent on the ease of surgical resection, the timing of diagnosis, and the malignant potential of the tumor. Whereas some GCTs can be diagnosed and treated prenatally, this review focuses on postnatal management of GCTs. We explore the embryological development, histopathology, biomarkers, clinical presentation, diagnostic features, and treatment of neonatal GCTs. Because the overall prognosis is excellent for the majority of patients with GCTs, we also discuss the potential long-term effects of antineoplastic agents used to treat patients with malignant disease.

Original languageEnglish (US)
Pages (from-to)205-215
Number of pages11
JournalCurrent Pediatric Reviews
Volume11
Issue number3
StatePublished - Jan 1 2015

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Germ Cell and Embryonal Neoplasms
Teratoma
Neoplasms
Sacrococcygeal Region
Newborn Infant
Hemangioma
Antineoplastic Agents
Ultrasonography
Biomarkers
Parturition

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Sandoval, J. A., & Williams, R. (2015). Neonatal germ cell tumors. Current Pediatric Reviews, 11(3), 205-215.

Neonatal germ cell tumors. / Sandoval, John A.; Williams, Regan.

In: Current Pediatric Reviews, Vol. 11, No. 3, 01.01.2015, p. 205-215.

Research output: Contribution to journalReview article

Sandoval, JA & Williams, R 2015, 'Neonatal germ cell tumors', Current Pediatric Reviews, vol. 11, no. 3, pp. 205-215.
Sandoval JA, Williams R. Neonatal germ cell tumors. Current Pediatric Reviews. 2015 Jan 1;11(3):205-215.
Sandoval, John A. ; Williams, Regan. / Neonatal germ cell tumors. In: Current Pediatric Reviews. 2015 ; Vol. 11, No. 3. pp. 205-215.
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