Neonates at risk for congenital syphilis

Radiographic and cerebrospinal fluid evaluations

Ajay Talati, Padmaja Koneru

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE: To review the infants at risk for congenital syphilis (CS) and determine the optimal use of evaluations such as cerebrospinal fluid (CSF), the venereal disease research laboratory (VDRL) test, and long bone radiography studies. METHODS: A retrospective chart review of all of the infants at risk for CS from January 1997 to December 2002 at the Regional Medical Center at Memphis was conducted. Subjects were identified from a database of prenatal maternal records. Infant charts showing a diagnosis of presumptive CS were reviewed and data were collected. RESULTS: Of the 24,245 deliveries, maternal serology (rapid plasma reagin and microhemagglutination for treponemal antibody) was reactive in 250 women during pregnancy. Of 92 infants with a presumptive diagnosis of syphilis, only 2 (2.1%) were symptomatic. CSF examination for VDRL was feasible in 74 (80%) of the 92 infants. Only 1 (1.35%) of the 74 infants had a positive CSF-VDRL. Three infants had radiographic changes that were consistent with CS. CONCLUSIONS: The burden of syphilis in pregnancy remains high. Proper evaluation of neonates is important in preventing long-term consequences. The frequency of positive CSF and long bone radiography studies remains low. These evaluations should be made based on the symptoms and plan of treatment for individual neonates.

Original languageEnglish (US)
Pages (from-to)827-830
Number of pages4
JournalSouthern medical journal
Volume104
Issue number12
DOIs
StatePublished - Dec 1 2011

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Congenital Syphilis
Cerebrospinal Fluid
Newborn Infant
Sexually Transmitted Diseases
Syphilis
Radiography
Research
Mothers
Reagins
Bone and Bones
Pregnancy
Serology
Databases
Antibodies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Neonates at risk for congenital syphilis : Radiographic and cerebrospinal fluid evaluations. / Talati, Ajay; Koneru, Padmaja.

In: Southern medical journal, Vol. 104, No. 12, 01.12.2011, p. 827-830.

Research output: Contribution to journalArticle

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