Nephrotoxicity of mercuric chloride, methylmercury and cinnabar-containing Zhu-Sha-An-Shen-Wan in rats

Jing Zhen Shi, Feng Kang, Qin Wu, Yuan Fu Lu, Jie Liu, Yujian Kang

Research output: Contribution to journalArticle

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Abstract

Cinnabar (HgS) is used in traditional medicines, and total Hg content is used for risk assessment of cinnabar-containing traditional medicines such as Zhu-Sha-An-Shen-Wan (ZSASW). Is ZSASW or cinnabar toxicologically similar to common mercurials? Adult Sprague-Dawley rats were gavaged with ZSASW (1.4g/kg), cinnabar (0.2g/kg), HgCl2 (0.02g/kg), MeHg (0.001g/kg), or saline daily for 60 days, and toxicity was determined. Animal body-weight gain was decreased by HgCl2 and MeHg. Blood urea nitrogen (BUN) was increased by MeHg. Histology showed severe kidney injury following MeHg and HgCl2 treatments, but mild after ZSASW and cinnabar. Renal Hg contents were markedly increased in the HgCl2 and MeHg groups but were not elevated in the ZSASW and cinnabar groups. The expression of kidney injury molecule-1 was increased 50-fold by MeHg, 4-fold by HgCl2, but was unaltered by ZSASW and cinnabar; the expression of matrilysin was increased 3-fold by MeHg. In contrast, the expression of N-cadherin was decreased by HgCl2. Thus, ZSASW and cinnabar are much less nephrotoxic than HgCl2 and MeHg, indicating that chemical forms of mercury underlie their disposition and toxicity.

Original languageEnglish (US)
Pages (from-to)194-200
Number of pages7
JournalToxicology Letters
Volume200
Issue number3
DOIs
StatePublished - Feb 5 2011

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Mercuric Chloride
Rats
Traditional Medicine
Kidney
Medicine
Toxicity
Matrix Metalloproteinase 7
Histology
Zhu-Sha-An-Shen-Wan
cinnabar
Blood Urea Nitrogen
Wounds and Injuries
Cadherins
Mercury
Risk assessment
Weight Gain
Sprague Dawley Rats
Urea
Animals
Blood

All Science Journal Classification (ASJC) codes

  • Toxicology

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Nephrotoxicity of mercuric chloride, methylmercury and cinnabar-containing Zhu-Sha-An-Shen-Wan in rats. / Shi, Jing Zhen; Kang, Feng; Wu, Qin; Lu, Yuan Fu; Liu, Jie; Kang, Yujian.

In: Toxicology Letters, Vol. 200, No. 3, 05.02.2011, p. 194-200.

Research output: Contribution to journalArticle

Shi, Jing Zhen ; Kang, Feng ; Wu, Qin ; Lu, Yuan Fu ; Liu, Jie ; Kang, Yujian. / Nephrotoxicity of mercuric chloride, methylmercury and cinnabar-containing Zhu-Sha-An-Shen-Wan in rats. In: Toxicology Letters. 2011 ; Vol. 200, No. 3. pp. 194-200.
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