Net protein anabolism with hypocaloric parenteral nutrition in obese stressed patients

Roland Dickerson, E. F. Rosato, J. L. Mullen

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Thirteen obese patients requiring parenteral nutrition for postoperative complications were studied prospectively to evaluate the efficacy of hypocaloric, high-protein parenteral feeding. Nonprotein, caloric intake averaged 881 kcal/d or 51.5% of the patients' measured resting energy expenditure. Protein intake averaged 2.13 ± 0.59 g/kg IBW. Serum albumin and TIBC increased significantly (2.8 ± 0.5 g/dL to 3.2 ± 0.4 g/dL, p < 0.01, and 196 ± 39 μg/dL to 248 ± 49 μg/dL, p < 0.05, respectively), and subjects lost weight (120.0 ± 60.0 kg to 109.7 ± 32.5 kg, p < 0.05). Nitrogen balance studies in eight subjects suggested nitrogen equilibrium or positive balance can be achieved (+2.4 ± 1.9 g/d). All patients exhibited complete tissue healing of wounds and abscess cavities and closure of fistulae. In obese, protein-depleted surgical patients net protein anabolism and clinical efficacy can be achieved with hypocaloric, high-protein feeding. Abundant endogenous fat stores provide obligatory energy.

Original languageEnglish (US)
Pages (from-to)747-755
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume44
Issue number6
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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Parenteral Nutrition
Proteins
Nitrogen
Energy Intake
Serum Albumin
Wound Healing
Abscess
Energy Metabolism
Fistula
Fats
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Net protein anabolism with hypocaloric parenteral nutrition in obese stressed patients. / Dickerson, Roland; Rosato, E. F.; Mullen, J. L.

In: American Journal of Clinical Nutrition, Vol. 44, No. 6, 01.01.1986, p. 747-755.

Research output: Contribution to journalArticle

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