Neural correlates of efficacy of voice therapy in Parkinson's disease identified by performance-correlation analysis

Shalini Narayana, Peter T. Fox, Wei Zhang, Crystal Franklin, Donald A. Robin, Deanie Vogel, Lorraine O. Ramig

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

LSVTV® LOUD (Lee Silverman Voice Treatment) is efficacious in the treatment of speech disorders in idiopathic Parkinson's disease (IPD), particularly hypophonia. Functional imaging in patients with IPD has shown abnormalities in several speech regions and changes in these areas immediately following treatment. This study serves to extend the analysis by correlating changes of regional neural activity with the main behavioral change following treatment, namely, increased vocal intensity. Ten IPD participants with hypophonia were studied before and after LSVT LOUD. Cerebral blood flow during rest and reading conditions were measured by H215O- positron emission tomography. Z-score images were generated by contrasting reading with rest conditions for pre- and post-LSVT LOUD sessions. Neuronal activity during reading in the pre- versus post-LSVT LOUD contrast was correlated with corresponding change in vocal intensity to generate correlation images. Behaviorally, vocal intensity for speech tasks increased significantly after LSVT LOUD. The contrast and correlation analyses indicate a treatment-dependent shift to the right hemisphere with modification in the speech motor regions as well as in prefrontal and temporal areas. We interpret the modification of activity in these regions to be a top-down effect of LSVT LOUD. The absence of an effect of LSVT LOUD on the basal ganglion supports this argument. Our findings indicate that the therapeutic effect of LSVT LOUD in IPD hypophonia results from a shift in cortical activity to the right hemisphere. These findings demonstrate that the short-term changes in the speech motor and multimodal integration areas can occur in a top-down manner.

Original languageEnglish (US)
Pages (from-to)222-236
Number of pages15
JournalHuman Brain Mapping
Volume31
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

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Parkinson Disease
Reading
Cerebrovascular Circulation
Therapeutics
Speech Disorders
Therapeutic Uses
Basal Ganglia
Positron-Emission Tomography

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Neural correlates of efficacy of voice therapy in Parkinson's disease identified by performance-correlation analysis. / Narayana, Shalini; Fox, Peter T.; Zhang, Wei; Franklin, Crystal; Robin, Donald A.; Vogel, Deanie; Ramig, Lorraine O.

In: Human Brain Mapping, Vol. 31, No. 2, 01.02.2010, p. 222-236.

Research output: Contribution to journalArticle

Narayana, Shalini ; Fox, Peter T. ; Zhang, Wei ; Franklin, Crystal ; Robin, Donald A. ; Vogel, Deanie ; Ramig, Lorraine O. / Neural correlates of efficacy of voice therapy in Parkinson's disease identified by performance-correlation analysis. In: Human Brain Mapping. 2010 ; Vol. 31, No. 2. pp. 222-236.
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