Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior

Reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence

Subimal Datta, Robert Ross MacLean

Research output: Contribution to journalReview article

187 Citations (Scopus)

Abstract

At its most basic level, the function of mammalian sleep can be described as a restorative process of the brain and body; recently, however, progressive research has revealed a host of vital functions to which sleep is essential. Although many excellent reviews on sleep behavior have been published, none have incorporated contemporary studies examining the molecular mechanisms that govern the various stages of sleep. Utilizing a holistic approach, this review is focused on the basic mechanisms involved in the transition from wakefulness, initiation of sleep and the subsequent generation of slow-wave sleep and rapid eye movement (REM) sleep. Additionally, using recent molecular studies and experimental evidence that provides a direct link to sleep as a behavior, we have developed a new model, the cellular-molecular-network model, explaining the mechanisms responsible for regulating REM sleep. By analyzing the fundamental neurobiological mechanisms responsible for the generation and maintenance of sleep-wake behavior in mammals, we intend to provide a broader understanding of our present knowledge in the field of sleep research.

Original languageEnglish (US)
Pages (from-to)775-824
Number of pages50
JournalNeuroscience and Biobehavioral Reviews
Volume31
Issue number5
DOIs
StatePublished - May 4 2007

Fingerprint

Inclusion Bodies
Sleep
REM Sleep
Molecular Models
Wakefulness
Sleep Stages
Research
Mammals
Maintenance

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

@article{080fa00e2b314abfbc0d69afe87ce73f,
title = "Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: Reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence",
abstract = "At its most basic level, the function of mammalian sleep can be described as a restorative process of the brain and body; recently, however, progressive research has revealed a host of vital functions to which sleep is essential. Although many excellent reviews on sleep behavior have been published, none have incorporated contemporary studies examining the molecular mechanisms that govern the various stages of sleep. Utilizing a holistic approach, this review is focused on the basic mechanisms involved in the transition from wakefulness, initiation of sleep and the subsequent generation of slow-wave sleep and rapid eye movement (REM) sleep. Additionally, using recent molecular studies and experimental evidence that provides a direct link to sleep as a behavior, we have developed a new model, the cellular-molecular-network model, explaining the mechanisms responsible for regulating REM sleep. By analyzing the fundamental neurobiological mechanisms responsible for the generation and maintenance of sleep-wake behavior in mammals, we intend to provide a broader understanding of our present knowledge in the field of sleep research.",
author = "Subimal Datta and MacLean, {Robert Ross}",
year = "2007",
month = "5",
day = "4",
doi = "10.1016/j.neubiorev.2007.02.004",
language = "English (US)",
volume = "31",
pages = "775--824",
journal = "Neuroscience and Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior

T2 - Reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence

AU - Datta, Subimal

AU - MacLean, Robert Ross

PY - 2007/5/4

Y1 - 2007/5/4

N2 - At its most basic level, the function of mammalian sleep can be described as a restorative process of the brain and body; recently, however, progressive research has revealed a host of vital functions to which sleep is essential. Although many excellent reviews on sleep behavior have been published, none have incorporated contemporary studies examining the molecular mechanisms that govern the various stages of sleep. Utilizing a holistic approach, this review is focused on the basic mechanisms involved in the transition from wakefulness, initiation of sleep and the subsequent generation of slow-wave sleep and rapid eye movement (REM) sleep. Additionally, using recent molecular studies and experimental evidence that provides a direct link to sleep as a behavior, we have developed a new model, the cellular-molecular-network model, explaining the mechanisms responsible for regulating REM sleep. By analyzing the fundamental neurobiological mechanisms responsible for the generation and maintenance of sleep-wake behavior in mammals, we intend to provide a broader understanding of our present knowledge in the field of sleep research.

AB - At its most basic level, the function of mammalian sleep can be described as a restorative process of the brain and body; recently, however, progressive research has revealed a host of vital functions to which sleep is essential. Although many excellent reviews on sleep behavior have been published, none have incorporated contemporary studies examining the molecular mechanisms that govern the various stages of sleep. Utilizing a holistic approach, this review is focused on the basic mechanisms involved in the transition from wakefulness, initiation of sleep and the subsequent generation of slow-wave sleep and rapid eye movement (REM) sleep. Additionally, using recent molecular studies and experimental evidence that provides a direct link to sleep as a behavior, we have developed a new model, the cellular-molecular-network model, explaining the mechanisms responsible for regulating REM sleep. By analyzing the fundamental neurobiological mechanisms responsible for the generation and maintenance of sleep-wake behavior in mammals, we intend to provide a broader understanding of our present knowledge in the field of sleep research.

UR - http://www.scopus.com/inward/record.url?scp=34247555902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247555902&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2007.02.004

DO - 10.1016/j.neubiorev.2007.02.004

M3 - Review article

VL - 31

SP - 775

EP - 824

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

IS - 5

ER -