Neurocognitive functioning in pediatric craniopharyngioma

performance before treatment with proton therapy

Ashley S. Fournier-Goodnight, Jason M. Ashford, Thomas E. Merchant, Frederick Boop, Daniel J. Indelicato, Lei Wang, Hui Zhang, Heather M. Conklin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The goal of this study was to investigate the impact of patient-, disease-, and treatment-related variables upon neurocognitive outcomes in pediatric patients with craniopharyngioma prior to treatment with proton therapy or observation after radical resection. For all participants (N = 104), relevant clinical and demographic variables were attained and neurocognitive evaluations completed prior to irradiation or planned observation. One-sample t-tests were conducted to compare performance to published normative data. Linear models were used to investigate predictors of performance on measures where performance was below normative expectations. Participants showed poorer performance in comparison to the normative group across neurocognitive domains including executive functions (e.g., working memory; Wechsler Digit Span Backward p = 0.03), learning and memory (e.g., California Verbal Learning Test [CVLT] Total T p = 0.00), and fine-motor coordination (e.g., Grooved Pegboard Dominant Hand p = 0.00). Poor performance across areas was predicted by presurgical hypothalamic involvement (e.g., Behavior Rating Inventory of Executive Function Working Memory Index Grade 2 β = −7.68, p = 0.03; CVLT Total T Grade 2 β = 7.94, p = 0.04; Grade 3 β = −9.80, p = 0.00), extent of surgery (e.g., CVLT Total T Resection β = −7.77, p = 0.04; Grooved Pegboard Dominant Hand β = −1.58, p = 0.04), and vision status (e.g., CVLT Total T Reduced vision without impairment β = −10.01, p = 0.02; Grooved Pegboard Dominant Hand Bilateral field defect β = −1.45, p = 0.01; Reduced vision without impairment β = −2.30, p = 0.00). This study demonstrated that patients with craniopharyngioma show weaker neurocognitive performance in comparison to the normative population resulting from tumor, events leading to diagnosis, and early surgical intervention. Systematic investigation of neurocognitive performance before treatment with radiation therapy is essential to evaluating the potential risks and benefits of newer methods of radiation therapy including proton therapy.

Original languageEnglish (US)
Pages (from-to)97-105
Number of pages9
JournalJournal of Neuro-Oncology
Volume134
Issue number1
DOIs
StatePublished - Aug 1 2017

Fingerprint

Proton Therapy
Craniopharyngioma
Verbal Learning
Pediatrics
Low Vision
Hand
Executive Function
Short-Term Memory
Radiotherapy
Observation
Therapeutics
Linear Models
Demography
Learning
Equipment and Supplies
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

Fournier-Goodnight, A. S., Ashford, J. M., Merchant, T. E., Boop, F., Indelicato, D. J., Wang, L., ... Conklin, H. M. (2017). Neurocognitive functioning in pediatric craniopharyngioma: performance before treatment with proton therapy. Journal of Neuro-Oncology, 134(1), 97-105. https://doi.org/10.1007/s11060-017-2492-y

Neurocognitive functioning in pediatric craniopharyngioma : performance before treatment with proton therapy. / Fournier-Goodnight, Ashley S.; Ashford, Jason M.; Merchant, Thomas E.; Boop, Frederick; Indelicato, Daniel J.; Wang, Lei; Zhang, Hui; Conklin, Heather M.

In: Journal of Neuro-Oncology, Vol. 134, No. 1, 01.08.2017, p. 97-105.

Research output: Contribution to journalArticle

Fournier-Goodnight, AS, Ashford, JM, Merchant, TE, Boop, F, Indelicato, DJ, Wang, L, Zhang, H & Conklin, HM 2017, 'Neurocognitive functioning in pediatric craniopharyngioma: performance before treatment with proton therapy', Journal of Neuro-Oncology, vol. 134, no. 1, pp. 97-105. https://doi.org/10.1007/s11060-017-2492-y
Fournier-Goodnight, Ashley S. ; Ashford, Jason M. ; Merchant, Thomas E. ; Boop, Frederick ; Indelicato, Daniel J. ; Wang, Lei ; Zhang, Hui ; Conklin, Heather M. / Neurocognitive functioning in pediatric craniopharyngioma : performance before treatment with proton therapy. In: Journal of Neuro-Oncology. 2017 ; Vol. 134, No. 1. pp. 97-105.
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