Neurocognitive Status in Long-Term Survivors of Childhood CNS Malignancies

A Report From the Childhood Cancer Survivor Study

Leah Ellenberg, Qi Liu, Gerard Gioia, Yutaka Yasui, Roger J. Packer, Ann Mertens, Sarah S. Donaldson, Marilyn Stovall, Nina Kadan-Lottick, Gregory Armstrong, Leslie L. Robison, Lonnie K. Zeltzer

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

To assess neurocognitive functioning in adult survivors of childhood Central Nervous System (CNS) malignancy, a large group of CNS malignancy survivors were compared to survivors of non-CNS malignancy and siblings without cancer on a self-report instrument (CCSS-NCQ) assessing four factors, Task Efficiency, Emotional Regulation, Organization and Memory. Additional multiple linear regressions were used to assess the contribution of demographic, illness, and treatment variables to reported neurocognitive functioning in CNS malignancy survivors and the relationship of reported neurocognitive functioning to socioeconomic indicators. Survivors of CNS malignancy reported significantly greater neurocognitive impairment on all CCSS-NCQ factors than non-CNS cancer survivors or siblings (p < .01). Within the CNS malignancy group, medical complications (hearing deficits, paralysis and cerebrovascular incidents) resulted in a greater likelihood of reported deficits on all CCSS-NCQ factors. Total or partial brain irradiation and ventriculoperitoneal (VP) shunt placement was associated with greater impairment on Task Efficiency and Memory. Female gender was associated with a greater likelihood of impaired scores on Task Efficiency and Emotional Regulation, while diagnosis before age 2 years resulted in less likelihood of reported impairment on the Memory factor. CNS malignancy survivors with more impaired CCSS-NCQ scores demonstrated significantly lower educational attainment (p < .01), less household income (p < .001), less full time employment (p < .001), and fewer marriages (p < .001). Survivors of childhood CNS malignancy were found to be at significant risk for neurocognitive impairment that continues to adulthood and is correlated with lower socioeconomic achievement.

Original languageEnglish (US)
Pages (from-to)705-717
Number of pages13
JournalNeuropsychology
Volume23
Issue number6
DOIs
StatePublished - Nov 1 2009

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Survivors
Central Nervous System
Neoplasms
Efficiency
Nervous System
Siblings
Ventriculoperitoneal Shunt
Marriage
Paralysis
Self Report
Hearing
Linear Models
Demography
Organizations
Brain

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology

Cite this

Ellenberg, L., Liu, Q., Gioia, G., Yasui, Y., Packer, R. J., Mertens, A., ... Zeltzer, L. K. (2009). Neurocognitive Status in Long-Term Survivors of Childhood CNS Malignancies: A Report From the Childhood Cancer Survivor Study. Neuropsychology, 23(6), 705-717. https://doi.org/10.1037/a0016674

Neurocognitive Status in Long-Term Survivors of Childhood CNS Malignancies : A Report From the Childhood Cancer Survivor Study. / Ellenberg, Leah; Liu, Qi; Gioia, Gerard; Yasui, Yutaka; Packer, Roger J.; Mertens, Ann; Donaldson, Sarah S.; Stovall, Marilyn; Kadan-Lottick, Nina; Armstrong, Gregory; Robison, Leslie L.; Zeltzer, Lonnie K.

In: Neuropsychology, Vol. 23, No. 6, 01.11.2009, p. 705-717.

Research output: Contribution to journalArticle

Ellenberg, L, Liu, Q, Gioia, G, Yasui, Y, Packer, RJ, Mertens, A, Donaldson, SS, Stovall, M, Kadan-Lottick, N, Armstrong, G, Robison, LL & Zeltzer, LK 2009, 'Neurocognitive Status in Long-Term Survivors of Childhood CNS Malignancies: A Report From the Childhood Cancer Survivor Study', Neuropsychology, vol. 23, no. 6, pp. 705-717. https://doi.org/10.1037/a0016674
Ellenberg, Leah ; Liu, Qi ; Gioia, Gerard ; Yasui, Yutaka ; Packer, Roger J. ; Mertens, Ann ; Donaldson, Sarah S. ; Stovall, Marilyn ; Kadan-Lottick, Nina ; Armstrong, Gregory ; Robison, Leslie L. ; Zeltzer, Lonnie K. / Neurocognitive Status in Long-Term Survivors of Childhood CNS Malignancies : A Report From the Childhood Cancer Survivor Study. In: Neuropsychology. 2009 ; Vol. 23, No. 6. pp. 705-717.
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