Neurocysticercosis among patients with cerebral gliomas

Oscar H. Del Brutto, Pablo R. Castillo, Ivän X. Mena, Amado Freire

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: Parasites have been implicated in the pathogenesis of human cancer. Anecdotal reports have suggested an association between neurocysticercosis and brain tumors. Objective: To determine whether neurocysticercosis is a risk factor for cerebral glioma. Design: Case- control study. Setting: A university general hospital and a cancer referral center. Patients: Forty-three consecutive patients with a cerebral glioma and 172 controls matched for age, sex, and socioeconomic status. Methods: We determined the ratio between the frequency of neurocysticercosis in patients with a cerebral glioma and in matched controls. We also evaluated differences in the characteristics of the patients and in the histological type of the neoplasm among case patients with and without neurocysticercosis. In addition, we noted relationships between the location of the cerebral glioma and that of parasitic lesions. Results: Eight (16.8%) of 43 patients with a glioma and 5 (2.9%) of 172 controls had neurocysticercosis (P<.001). The odds ratio for this association was 7.63 (95% confidence interval, 2.03-31.09). Patients with glioma and neurocysticercosis were older than those without neurocysticercosis (mean [±SD] age, 62.75±18.34 years vs 44.69±14.04 years; P=.02). Glioblastoma multiforme was more frequent among case patients with neurocysticercosis than among those without neurocysticercosis (87.5% vs 48.6%); however, this difference was not statistically significant (P=.24). Six of the 8 patients with neurocysticercosis and a cerebral glioma had calcified parasitic lesions within and around the tumor. Conclusions: Results from this study suggest that neurocysticercosis is a risk factor for cerebral glioma. The intense astrocytic gliosis that surrounds calcified cysticerci, together with the suppression of the cellular immune response induced by cysticerci, may contribute to the development of malignant glial cells in patients with neurocysticercosis.

Original languageEnglish (US)
Pages (from-to)1125-1128
Number of pages4
JournalArchives of Neurology
Volume54
Issue number9
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Neurocysticercosis
Glioma
Cysticercus
Neoplasms by Histologic Type
Neoplasms
Gliosis
Glioblastoma
Social Class
Cellular Immunity
Brain Neoplasms
Neuroglia
General Hospitals
Case-Control Studies

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Neurocysticercosis among patients with cerebral gliomas. / Del Brutto, Oscar H.; Castillo, Pablo R.; Mena, Ivän X.; Freire, Amado.

In: Archives of Neurology, Vol. 54, No. 9, 01.01.1997, p. 1125-1128.

Research output: Contribution to journalArticle

Del Brutto, Oscar H. ; Castillo, Pablo R. ; Mena, Ivän X. ; Freire, Amado. / Neurocysticercosis among patients with cerebral gliomas. In: Archives of Neurology. 1997 ; Vol. 54, No. 9. pp. 1125-1128.
@article{0eda9408100b45a8be55aed8b3740a04,
title = "Neurocysticercosis among patients with cerebral gliomas",
abstract = "Background: Parasites have been implicated in the pathogenesis of human cancer. Anecdotal reports have suggested an association between neurocysticercosis and brain tumors. Objective: To determine whether neurocysticercosis is a risk factor for cerebral glioma. Design: Case- control study. Setting: A university general hospital and a cancer referral center. Patients: Forty-three consecutive patients with a cerebral glioma and 172 controls matched for age, sex, and socioeconomic status. Methods: We determined the ratio between the frequency of neurocysticercosis in patients with a cerebral glioma and in matched controls. We also evaluated differences in the characteristics of the patients and in the histological type of the neoplasm among case patients with and without neurocysticercosis. In addition, we noted relationships between the location of the cerebral glioma and that of parasitic lesions. Results: Eight (16.8{\%}) of 43 patients with a glioma and 5 (2.9{\%}) of 172 controls had neurocysticercosis (P<.001). The odds ratio for this association was 7.63 (95{\%} confidence interval, 2.03-31.09). Patients with glioma and neurocysticercosis were older than those without neurocysticercosis (mean [±SD] age, 62.75±18.34 years vs 44.69±14.04 years; P=.02). Glioblastoma multiforme was more frequent among case patients with neurocysticercosis than among those without neurocysticercosis (87.5{\%} vs 48.6{\%}); however, this difference was not statistically significant (P=.24). Six of the 8 patients with neurocysticercosis and a cerebral glioma had calcified parasitic lesions within and around the tumor. Conclusions: Results from this study suggest that neurocysticercosis is a risk factor for cerebral glioma. The intense astrocytic gliosis that surrounds calcified cysticerci, together with the suppression of the cellular immune response induced by cysticerci, may contribute to the development of malignant glial cells in patients with neurocysticercosis.",
author = "{Del Brutto}, {Oscar H.} and Castillo, {Pablo R.} and Mena, {Iv{\"a}n X.} and Amado Freire",
year = "1997",
month = "1",
day = "1",
doi = "10.1001/archneur.1997.00550210057013",
language = "English (US)",
volume = "54",
pages = "1125--1128",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "9",

}

TY - JOUR

T1 - Neurocysticercosis among patients with cerebral gliomas

AU - Del Brutto, Oscar H.

AU - Castillo, Pablo R.

AU - Mena, Ivän X.

AU - Freire, Amado

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Background: Parasites have been implicated in the pathogenesis of human cancer. Anecdotal reports have suggested an association between neurocysticercosis and brain tumors. Objective: To determine whether neurocysticercosis is a risk factor for cerebral glioma. Design: Case- control study. Setting: A university general hospital and a cancer referral center. Patients: Forty-three consecutive patients with a cerebral glioma and 172 controls matched for age, sex, and socioeconomic status. Methods: We determined the ratio between the frequency of neurocysticercosis in patients with a cerebral glioma and in matched controls. We also evaluated differences in the characteristics of the patients and in the histological type of the neoplasm among case patients with and without neurocysticercosis. In addition, we noted relationships between the location of the cerebral glioma and that of parasitic lesions. Results: Eight (16.8%) of 43 patients with a glioma and 5 (2.9%) of 172 controls had neurocysticercosis (P<.001). The odds ratio for this association was 7.63 (95% confidence interval, 2.03-31.09). Patients with glioma and neurocysticercosis were older than those without neurocysticercosis (mean [±SD] age, 62.75±18.34 years vs 44.69±14.04 years; P=.02). Glioblastoma multiforme was more frequent among case patients with neurocysticercosis than among those without neurocysticercosis (87.5% vs 48.6%); however, this difference was not statistically significant (P=.24). Six of the 8 patients with neurocysticercosis and a cerebral glioma had calcified parasitic lesions within and around the tumor. Conclusions: Results from this study suggest that neurocysticercosis is a risk factor for cerebral glioma. The intense astrocytic gliosis that surrounds calcified cysticerci, together with the suppression of the cellular immune response induced by cysticerci, may contribute to the development of malignant glial cells in patients with neurocysticercosis.

AB - Background: Parasites have been implicated in the pathogenesis of human cancer. Anecdotal reports have suggested an association between neurocysticercosis and brain tumors. Objective: To determine whether neurocysticercosis is a risk factor for cerebral glioma. Design: Case- control study. Setting: A university general hospital and a cancer referral center. Patients: Forty-three consecutive patients with a cerebral glioma and 172 controls matched for age, sex, and socioeconomic status. Methods: We determined the ratio between the frequency of neurocysticercosis in patients with a cerebral glioma and in matched controls. We also evaluated differences in the characteristics of the patients and in the histological type of the neoplasm among case patients with and without neurocysticercosis. In addition, we noted relationships between the location of the cerebral glioma and that of parasitic lesions. Results: Eight (16.8%) of 43 patients with a glioma and 5 (2.9%) of 172 controls had neurocysticercosis (P<.001). The odds ratio for this association was 7.63 (95% confidence interval, 2.03-31.09). Patients with glioma and neurocysticercosis were older than those without neurocysticercosis (mean [±SD] age, 62.75±18.34 years vs 44.69±14.04 years; P=.02). Glioblastoma multiforme was more frequent among case patients with neurocysticercosis than among those without neurocysticercosis (87.5% vs 48.6%); however, this difference was not statistically significant (P=.24). Six of the 8 patients with neurocysticercosis and a cerebral glioma had calcified parasitic lesions within and around the tumor. Conclusions: Results from this study suggest that neurocysticercosis is a risk factor for cerebral glioma. The intense astrocytic gliosis that surrounds calcified cysticerci, together with the suppression of the cellular immune response induced by cysticerci, may contribute to the development of malignant glial cells in patients with neurocysticercosis.

UR - http://www.scopus.com/inward/record.url?scp=0030776811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030776811&partnerID=8YFLogxK

U2 - 10.1001/archneur.1997.00550210057013

DO - 10.1001/archneur.1997.00550210057013

M3 - Article

VL - 54

SP - 1125

EP - 1128

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 9

ER -