Neuroendocrine neoplasms of the larynx

Samuel Mark Overholt, Donald T. Donovan, Mary R. Schwartz, Rodolfo Laucirica, Linda K. Green, Bobby R. Alford

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Neuroendocrine neoplasms of the larynx are a rare group of tumors that include carcinoid tumor, atypical carcinoid tumor, and small cell carcinoma. These neoplasms pose interesting diagnostic, prognostic, and therapeutic dilemmas, and they are, as a whole, aggressive tumors with a tendency for local and distant spread. The authors of this study examined six new cases of laryngeal neuroendocrine neoplasms. One case manifested itself as a primary atypical carcinoid tumor and caused a "carcinoid syndrome." The remaining five cases were small cell carcinomas of the larynx. Histologic, immunocytochemical, DNA flow cytometric, and p53 studies were performed on all cases. The expression of neuron-specific enolase and chromogranin were the most useful markers in this group of tumors. Overexpression of p53 protein was present in the majority of cases, including the atypical carcinoid tumor. The implications of these studies for diagnosis, classification, and treatment are discussed.

Original languageEnglish (US)
Pages (from-to)789-794
Number of pages6
JournalLaryngoscope
Volume105
Issue number8
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Laryngeal Neoplasms
Carcinoid Tumor
Small Cell Carcinoma
Neoplasms
Chromogranins
Phosphopyruvate Hydratase
Larynx
DNA
Therapeutics
Proteins

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Overholt, S. M., Donovan, D. T., Schwartz, M. R., Laucirica, R., Green, L. K., & Alford, B. R. (1995). Neuroendocrine neoplasms of the larynx. Laryngoscope, 105(8), 789-794. https://doi.org/10.1288/00005537-199508000-00004

Neuroendocrine neoplasms of the larynx. / Overholt, Samuel Mark; Donovan, Donald T.; Schwartz, Mary R.; Laucirica, Rodolfo; Green, Linda K.; Alford, Bobby R.

In: Laryngoscope, Vol. 105, No. 8, 01.01.1995, p. 789-794.

Research output: Contribution to journalArticle

Overholt, SM, Donovan, DT, Schwartz, MR, Laucirica, R, Green, LK & Alford, BR 1995, 'Neuroendocrine neoplasms of the larynx', Laryngoscope, vol. 105, no. 8, pp. 789-794. https://doi.org/10.1288/00005537-199508000-00004
Overholt SM, Donovan DT, Schwartz MR, Laucirica R, Green LK, Alford BR. Neuroendocrine neoplasms of the larynx. Laryngoscope. 1995 Jan 1;105(8):789-794. https://doi.org/10.1288/00005537-199508000-00004
Overholt, Samuel Mark ; Donovan, Donald T. ; Schwartz, Mary R. ; Laucirica, Rodolfo ; Green, Linda K. ; Alford, Bobby R. / Neuroendocrine neoplasms of the larynx. In: Laryngoscope. 1995 ; Vol. 105, No. 8. pp. 789-794.
@article{04acfd4b7d9248b19004f409c9dbeac5,
title = "Neuroendocrine neoplasms of the larynx",
abstract = "Neuroendocrine neoplasms of the larynx are a rare group of tumors that include carcinoid tumor, atypical carcinoid tumor, and small cell carcinoma. These neoplasms pose interesting diagnostic, prognostic, and therapeutic dilemmas, and they are, as a whole, aggressive tumors with a tendency for local and distant spread. The authors of this study examined six new cases of laryngeal neuroendocrine neoplasms. One case manifested itself as a primary atypical carcinoid tumor and caused a {"}carcinoid syndrome.{"} The remaining five cases were small cell carcinomas of the larynx. Histologic, immunocytochemical, DNA flow cytometric, and p53 studies were performed on all cases. The expression of neuron-specific enolase and chromogranin were the most useful markers in this group of tumors. Overexpression of p53 protein was present in the majority of cases, including the atypical carcinoid tumor. The implications of these studies for diagnosis, classification, and treatment are discussed.",
author = "Overholt, {Samuel Mark} and Donovan, {Donald T.} and Schwartz, {Mary R.} and Rodolfo Laucirica and Green, {Linda K.} and Alford, {Bobby R.}",
year = "1995",
month = "1",
day = "1",
doi = "10.1288/00005537-199508000-00004",
language = "English (US)",
volume = "105",
pages = "789--794",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

TY - JOUR

T1 - Neuroendocrine neoplasms of the larynx

AU - Overholt, Samuel Mark

AU - Donovan, Donald T.

AU - Schwartz, Mary R.

AU - Laucirica, Rodolfo

AU - Green, Linda K.

AU - Alford, Bobby R.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Neuroendocrine neoplasms of the larynx are a rare group of tumors that include carcinoid tumor, atypical carcinoid tumor, and small cell carcinoma. These neoplasms pose interesting diagnostic, prognostic, and therapeutic dilemmas, and they are, as a whole, aggressive tumors with a tendency for local and distant spread. The authors of this study examined six new cases of laryngeal neuroendocrine neoplasms. One case manifested itself as a primary atypical carcinoid tumor and caused a "carcinoid syndrome." The remaining five cases were small cell carcinomas of the larynx. Histologic, immunocytochemical, DNA flow cytometric, and p53 studies were performed on all cases. The expression of neuron-specific enolase and chromogranin were the most useful markers in this group of tumors. Overexpression of p53 protein was present in the majority of cases, including the atypical carcinoid tumor. The implications of these studies for diagnosis, classification, and treatment are discussed.

AB - Neuroendocrine neoplasms of the larynx are a rare group of tumors that include carcinoid tumor, atypical carcinoid tumor, and small cell carcinoma. These neoplasms pose interesting diagnostic, prognostic, and therapeutic dilemmas, and they are, as a whole, aggressive tumors with a tendency for local and distant spread. The authors of this study examined six new cases of laryngeal neuroendocrine neoplasms. One case manifested itself as a primary atypical carcinoid tumor and caused a "carcinoid syndrome." The remaining five cases were small cell carcinomas of the larynx. Histologic, immunocytochemical, DNA flow cytometric, and p53 studies were performed on all cases. The expression of neuron-specific enolase and chromogranin were the most useful markers in this group of tumors. Overexpression of p53 protein was present in the majority of cases, including the atypical carcinoid tumor. The implications of these studies for diagnosis, classification, and treatment are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0029102858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029102858&partnerID=8YFLogxK

U2 - 10.1288/00005537-199508000-00004

DO - 10.1288/00005537-199508000-00004

M3 - Article

VL - 105

SP - 789

EP - 794

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 8

ER -