Neuroendocrine Tumors of the Thymus

Analysis of Factors Affecting Survival in 254 Patients

Jennifer L. Sullivan, Benny Weksler

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background Neuroendocrine tumors of the thymus (NETT) constitute less than 5% of all anterior mediastinal masses but are aggressive and lead to poor overall survival. This study was designed to evaluate factors that influence the prognosis of patients with NETT and the role of surgical intervention in survival. Methods We analyzed the Surveillance, Epidemiology, and End Results cancer database to identify patients with NETT. We performed univariate and multivariate analyses to identify prognostic factors among demographic, tumor, and treatment variables. Results In 254 patients identified with NETT, the median overall survival time was 73 months, with a 5-year survival rate of 56%. Patients who underwent surgical therapy had a significantly longer median survival time than did those who did not undergo surgical therapy (109 months vs 46 months, p < 0.001). In multivariate analysis, surgical resection, Masaoka-Koga stage, and tumor size were significant predictors of survival. Conclusions Our study found that surgical resection, Masaoka-Koga stage, and tumor size are significant prognostic factors in patients with NETT. Complete surgical resection continues, rightfully, to be the mainstay in the treatment of this rare disease.

Original languageEnglish (US)
Pages (from-to)935-939
Number of pages5
JournalAnnals of Thoracic Surgery
Volume103
Issue number3
DOIs
StatePublished - Mar 1 2017

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Neuroendocrine Tumors
Thymus Gland
Statistical Factor Analysis
Survival
Neoplasms
Multivariate Analysis
Therapeutics
Rare Diseases
Epidemiology
Survival Rate
Demography
Databases

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Neuroendocrine Tumors of the Thymus : Analysis of Factors Affecting Survival in 254 Patients. / Sullivan, Jennifer L.; Weksler, Benny.

In: Annals of Thoracic Surgery, Vol. 103, No. 3, 01.03.2017, p. 935-939.

Research output: Contribution to journalArticle

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abstract = "Background Neuroendocrine tumors of the thymus (NETT) constitute less than 5{\%} of all anterior mediastinal masses but are aggressive and lead to poor overall survival. This study was designed to evaluate factors that influence the prognosis of patients with NETT and the role of surgical intervention in survival. Methods We analyzed the Surveillance, Epidemiology, and End Results cancer database to identify patients with NETT. We performed univariate and multivariate analyses to identify prognostic factors among demographic, tumor, and treatment variables. Results In 254 patients identified with NETT, the median overall survival time was 73 months, with a 5-year survival rate of 56{\%}. Patients who underwent surgical therapy had a significantly longer median survival time than did those who did not undergo surgical therapy (109 months vs 46 months, p < 0.001). In multivariate analysis, surgical resection, Masaoka-Koga stage, and tumor size were significant predictors of survival. Conclusions Our study found that surgical resection, Masaoka-Koga stage, and tumor size are significant prognostic factors in patients with NETT. Complete surgical resection continues, rightfully, to be the mainstay in the treatment of this rare disease.",
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AB - Background Neuroendocrine tumors of the thymus (NETT) constitute less than 5% of all anterior mediastinal masses but are aggressive and lead to poor overall survival. This study was designed to evaluate factors that influence the prognosis of patients with NETT and the role of surgical intervention in survival. Methods We analyzed the Surveillance, Epidemiology, and End Results cancer database to identify patients with NETT. We performed univariate and multivariate analyses to identify prognostic factors among demographic, tumor, and treatment variables. Results In 254 patients identified with NETT, the median overall survival time was 73 months, with a 5-year survival rate of 56%. Patients who underwent surgical therapy had a significantly longer median survival time than did those who did not undergo surgical therapy (109 months vs 46 months, p < 0.001). In multivariate analysis, surgical resection, Masaoka-Koga stage, and tumor size were significant predictors of survival. Conclusions Our study found that surgical resection, Masaoka-Koga stage, and tumor size are significant prognostic factors in patients with NETT. Complete surgical resection continues, rightfully, to be the mainstay in the treatment of this rare disease.

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