Neuromodulation, development and synaptic plasticity

Robert Foehring, Nancy M. Lorenzon

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We discuss parallels in the mechanisms underlying use-dependent synaptic plasticity during development and long-term potentiation (LTP) and long-term depression (LTD) in neocortical synapses. Neuromodulators, such as norepinephrine, serotonin, and acetylcholine have also been implicated in regulating both developmental plasticity and LTP/LTD. There are many potential levels of interaction between neuromodulators and plasticity. Ion channels are substrates for modulation in many cell types. We discuss examples of modulation of voltage-gated Ca2+ channels and Ca2+-dependent K+ channels and the consequences for neocortical pyramidal cell firing behaviour. At the time when developmental plasticity is most evident in rat cortex, the substrate for modulation is changing as the densities and relative proportions of various ion channels types are altered during ontogeny. We discuss examples of changes in K+ and Ca2+ channels and the consequence for modulation of neuronal activity.

Original languageEnglish (US)
Pages (from-to)45-61
Number of pages17
JournalCanadian Journal of Experimental Psychology
Volume53
Issue number1
DOIs
StatePublished - Jan 1 1999

Fingerprint

Neuronal Plasticity
Long-Term Potentiation
Ion Channels
Neurotransmitter Agents
Depression
Specific Gravity
Pyramidal Cells
Synapses
Acetylcholine
Serotonin
Norepinephrine

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology

Cite this

Neuromodulation, development and synaptic plasticity. / Foehring, Robert; Lorenzon, Nancy M.

In: Canadian Journal of Experimental Psychology, Vol. 53, No. 1, 01.01.1999, p. 45-61.

Research output: Contribution to journalArticle

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