Neuromuscular transmission studies in preeclamptic women receiving magnesium sulfate

Jaya Ramanathan, Baha M. Sibai, Rekha Pillai, John J. Angel

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The purpose of the study was to evaluate the neuromuscular transmission defect in preeclamptic women receiving intravenous magnesium sulfate and to study the correlation of the degree of defect with serum magnesium and calcium levels. The study population included: group 1, 14 preeclamptic women receiving magnesium sulfate and undergoing induction of labor; group 2, six preeclamptic women studied in the postpartum period while receiving magnesium sulfate; and group 3, 10 normotensive women undergoing induction of labor. The neuromuscular transmission studies were performed with standard techniques before and during the administration of magnesium sulfate. During magnesium sulfate therapy patients in groups 1 and 2 showed abnormal responses characterized by an initial low-amplitude muscle action potential followed by a progressive increase in the amplitudes of the successive responses. There was significant correlation between the degree of the neuromuscular transmission defect and serum magnesium levels, serum calcium levels, and the magnesium/calcium ratio in groups 1 and 2. All studies were normal in group 3. The findings confirm the occurrence of abnormal neuromuscular transmission in preeclamptic women receiving magnesium sulfate, and the intensity of the defect correlates significantly with increased serum magnesium levels and decreased serum calcium levels.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume158
Issue number1
DOIs
StatePublished - Jan 1 1988

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Magnesium Sulfate
Magnesium
Induced Labor
Calcium
Serum
Population Groups
Postpartum Period
Action Potentials
Muscles

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Neuromuscular transmission studies in preeclamptic women receiving magnesium sulfate. / Ramanathan, Jaya; Sibai, Baha M.; Pillai, Rekha; Angel, John J.

In: American Journal of Obstetrics and Gynecology, Vol. 158, No. 1, 01.01.1988, p. 40-46.

Research output: Contribution to journalArticle

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